D'Souza Ryan S, Eller Jennifer, Hoffmann Chelsey
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
J Pain Res. 2022 May 3;15:1297-1304. doi: 10.2147/JPR.S360645. eCollection 2022.
There is a paucity of data on pain diagnoses and analgesic utilization in medically underserved areas (MUAs). This study compared the prevalence of pain diagnoses and analgesic medication use between MUAs and non-medically underserved areas (N-MUAs) in Southern Minnesota and Western Wisconsin using the Rochester Epidemiology Project (REP) database.
Five-year prevalence per 100 people (January 1, 2011 to January 1, 2016) was extracted from the REP database for multiple pain diagnosis variables and analgesic medications. Primary outcomes included comparison of five-year prevalence of each pain diagnosis and analgesic between MUA and N-MUA; and association between index of medical underservice (IMU) score and five-year prevalence for each pain diagnosis and analgesic. Linear regression models were performed to assess associations and significance thresholds were adjusted per the Bonferroni approach to account for multiplicity.
The prevalence per 100 people for a diagnosis of chronic pain was similar between MUAs and N-MUAs (13.8 ± 2.5 vs 14.6 ± 2.0, P = 0.543). Similarly, prevalence per 100 people for other specific pain diagnoses including nonspecific chest pain, abdominal pain, lumbago, somatoform disorder, and painful respiration did not differ based on MUA status. In terms of analgesic use, prevalence per 100 people for use of opioids, non-opioid analgesics, salicylates, and NSAIDs did not differ based on MUA status. An association between higher IMU scores and lower prevalence of painful respiration was identified, although this was not significant after significance threshold adjustment per the Bonferroni method.
Our data suggest that there are no differences in several pain diagnoses and analgesic utilization between MUAs versus N-MUAs, and that the IMU score did not predict changes in prevalence of pain diagnoses or analgesic utilization. Future powered and national database studies are warranted to increase validity of findings to other populations outside of Southern Minnesota and Western Wisconsin.
关于医疗服务不足地区(MUA)疼痛诊断和镇痛药物使用的数据匮乏。本研究利用罗切斯特流行病学项目(REP)数据库,比较了明尼苏达州南部和威斯康星州西部MUA与非医疗服务不足地区(N-MUA)之间疼痛诊断和镇痛药物使用的患病率。
从REP数据库中提取每100人5年的患病率(2011年1月1日至2016年1月1日),涉及多个疼痛诊断变量和镇痛药物。主要结局包括比较MUA和N-MUA之间每种疼痛诊断和镇痛药物的5年患病率;以及医疗服务不足指数(IMU)得分与每种疼痛诊断和镇痛药物的5年患病率之间的关联。采用线性回归模型评估关联,并根据邦费罗尼方法调整显著性阈值以考虑多重性。
MUA和N-MUA之间每100人慢性疼痛诊断的患病率相似(13.8±2.5对14.6±2.0,P=0.543)。同样,根据MUA状态,每100人其他特定疼痛诊断的患病率,包括非特异性胸痛、腹痛、腰痛、躯体形式障碍和疼痛性呼吸,没有差异。在镇痛药物使用方面,根据MUA状态,每100人使用阿片类药物、非阿片类镇痛药、水杨酸盐和非甾体抗炎药的患病率没有差异。尽管根据邦费罗尼方法调整显著性阈值后这不显著,但发现IMU得分较高与疼痛性呼吸患病率较低之间存在关联。
我们的数据表明,MUA与N-MUA之间在几种疼痛诊断和镇痛药物使用方面没有差异,并且IMU得分不能预测疼痛诊断患病率或镇痛药物使用的变化。未来需要进行有足够样本量的全国性数据库研究,以提高研究结果对明尼苏达州南部和威斯康星州西部以外其他人群的有效性。