Reineke W
J Basic Microbiol. 1986;26(9):551-67. doi: 10.1002/jobm.3620260911.
Biodegradation of most naturally occurring compounds is relatively fast, since microorganisms have evolved appropriate enzyme systems. However, biodegradation is less likely in the case of man-made compounds like haloaromatics, which have structural features rarely or never encountered in natural products. One strategy to develop new metabolic activities for novel compounds by strains of microorganisms is by the alteration of their existing genetic information. The present paper summarizes results of studies where the degradation capabilities of bacteria were expanded by genetic material from external sources either by natural exchange or by cloning procedures.
由于微生物已经进化出了合适的酶系统，大多数天然存在的化合物的生物降解相对较快。然而，对于卤代芳烃等人工合成化合物来说，生物降解的可能性较小，因为这些化合物具有天然产物中很少或从未遇到过的结构特征。通过微生物菌株开发新化合物的新代谢活性的一种策略是改变其现有的遗传信息。本文总结了通过自然交换或克隆程序从外部来源获取遗传物质来扩展细菌降解能力的研究结果。
