A C-symmetric -heterocyclic carbene catalysed oxidative spiroannulation of isatin-derived enals: highly enantioselective synthesis of spirooxindole δ-lactones.

A C-symmetric -heterocyclic carbene (NHC)-catalysed activation of isatin-derived enals under oxidative conditions was achieved. The generated α,β-unsaturated acyl azolium species was efficiently trapped by 1,3-dicarbonyl compounds a Michael addition/spiroannualtion cascade, delivering a series of synthetically important spirooxindole δ-lactones with up to 96% enantioselectivity.