盐酸度洛西汀与氟康唑联合使用可降低新型隐球菌的细胞生长和荚膜大小。
Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans.
机构信息
Universidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, Departamento de Biociências e Diagnóstico Oral, Av. Engenheiro Francisco José Longo, 777, 12245-000 São José dos Campos, SP, Brazil.
Pós-Graduação em Enfermagem, Universidade de Guarulhos (UNG), Rua Engenheiro Prestes Maia, 88, 07023-070 Guarulhos, SP, Brazil.
出版信息
An Acad Bras Cienc. 2022 May 9;94(2):e20211021. doi: 10.1590/0001-3765202220211021. eCollection 2022.
This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast.
本研究旨在评估盐酸度洛西汀（DH）对新型隐球菌的影响。DH 的最小抑菌浓度（MIC）和最小杀菌浓度（MFC）分别为 18.5μg/ml，与氟康唑（FLZ）联合使用分别使 DH 和 FLZ 的 MIC 值降低了 16 倍和 4 倍。DH 和 DH 联合 FLZ 处理后，胶囊大小分别减少了 67%和 16%。因此，本研究表明 DH 对新型隐球菌具有活性，单独使用和与 FLZ 联合使用均可导致该酵母胶囊大小减小。
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