Hunan Cancer Hospital; Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013.
Institute of Oncology, Central South University, Changsha 4100011.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Jan 28;47(1):101-108. doi: 10.11817/j.issn.1672-7347.2022.210394.
gene is located on chromosome 17p13.3, and its product 14-3-3epsilon protein belongs to 14-3-3 protein family. As a molecular scaffold, participates in biological processes such as cell adhesion, cell cycle regulation, signal transduction and malignant transformation, and is closely related to many diseases. Overexpression of in breast cancer can increase the ability of proliferation, migration and invasion of breast cancer cells. In gastric cancer, acts as a negative regulator of and , which reduces their expression and inhibits the proliferation, migration, and invasion of gastric cancer cells, and enhances YWHAE-mediated transactivation of NF-κB through CagA. In colorectal cancer, lncRNA, as a sponge molecule of and , can compete for endogenous RNA through direct interaction with and , thus up-regulating and signaling pathways and promoting the cell cycle progression of the colorectal cancer. not only mediates tumorigenesis as a competitive endogenous RNA, but also affects gene expression through chromosome variation. For example, the fusion gene caused by t(10; 17) (q22; p13) may be associated with the development of endometrial stromal sarcoma. At the same time, the fusion transcript of and may also lead to the occurrence of endometrial stromal sarcoma. To understand the relationship between , and gene rearrangement/fusion and malignant tumor, fusion gene/translocation and tumor, gene polymorphism and mental illness, as well as the relationship between 17p13.3 region change and disease occurrence. It provides new idea and basis for understanding the effect of gene molecular mechanism and genetic variation on the disease progression, and for the targeted for the diseases.
基因位于 17p13.3 染色体上，其产物 14-3-3epsilon 蛋白属于 14-3-3 蛋白家族。作为一种分子支架，参与细胞黏附、细胞周期调控、信号转导和恶性转化等生物学过程，与多种疾病密切相关。在乳腺癌中，的过度表达可以增加乳腺癌细胞的增殖、迁移和侵袭能力。在胃癌中，作为和的负调节剂，降低其表达，抑制胃癌细胞的增殖、迁移和侵袭，并通过 CagA 增强 YWHAE 介导的 NF-κB 转录激活。在结直肠癌中，lncRNA 作为和的海绵分子，可以通过与和直接相互作用，竞争内源性 RNA，从而上调和信号通路，促进结直肠癌细胞的细胞周期进程。不仅作为竞争性内源性 RNA 介导肿瘤发生，还通过染色体变异影响基因表达。例如，t(10; 17)(q22;p13)引起的基因融合可能与子宫内膜间质肉瘤的发生有关。同时，和的融合转录本也可能导致子宫内膜间质肉瘤的发生。为了了解、和基因重排/融合与恶性肿瘤、融合基因/易位与肿瘤、基因多态性与精神疾病以及 17p13.3 区域变化与疾病发生之间的关系，为理解基因分子机制和遗传变异对疾病进展的影响，以及针对这些疾病的靶向治疗提供了新的思路和依据。
