a:1:{s:5:"en_US";s:51:"U.O. NPI Azienda Ospedaliero-Universitaria di Parma";}.
Child Neuropsychiatry, Dipartimento Assistenziale Integrato Salute Mentale Dipendenze Patologiche, Fidenza, Parma, Italy.
Acta Biomed. 2022 May 11;93(2):e2022041. doi: 10.23750/abm.v93i2.11187.
Intraventricular haemorrhage (IVH) is a cause of morbidity and mortality in preterm infants. It occurs primarily in preterm newborns with an incidence of about 20% and, despite the evolution of neonatal care that allows more and better survival, continues to be a cause of morbidity and mortality in all intensive care units. Our research aimed to evaluate the independent risk factors of mortality and the relative odds ratio for each degree of IVH.
In this retrospective study were included 96 preterm infants, born between 23^ and 36^ weeks of gestational age, which developed IVH of degree two-three-four diagnosed by means of cranial ultrasound. It was made a comparison within the sample by distinguishing the group with IVH degree two from degrees three and four.
IVH of degree three and four was independently associated with mortality. We found a higher number of deaths in the GAs <= 26 weeks (p <0.01), which was also an independent predictor of mortality.
With this study it was further highlighted the high mortality of patients with an elevated degrees of IVH and low birth weight and early gestational age. These data, of important clinical relevance, oblige us to find new therapeutic strategies aimed at reducing the serious consequences of that disease.
脑室内出血（IVH）是早产儿发病率和死亡率的一个重要原因。它主要发生在胎龄 23 至 36 周的早产儿中，发病率约为 20%，尽管新生儿护理的发展使得早产儿存活率更高、预后更好，但 IVH 仍然是所有重症监护病房发病率和死亡率的一个重要原因。我们的研究旨在评估死亡率的独立风险因素，以及 IVH 每一级别的相对优势比。
本回顾性研究纳入了 96 名胎龄为 23 至 36 周的早产儿，这些早产儿通过头颅超声诊断为 II 至 IV 级 IVH。通过将 II 级 IVH 组与 III 级和 IV 级 IVH 组进行比较，在样本中进行了比较。
III 级和 IV 级 IVH 与死亡率独立相关。我们发现，GA<=26 周的患儿死亡人数更高（p<0.01），GA 也是死亡率的独立预测因素。
本研究进一步强调了 IVH 程度较高、出生体重较低和胎龄较早的患者死亡率较高。这些具有重要临床意义的数据，促使我们寻找新的治疗策略，以降低该疾病的严重后果。
