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用于增强胶质母细胞瘤癌细胞的放射效果及机械破坏的多功能磁性微盘。

Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells.

作者信息

Leulmi Pichot Selma, Bentouati Sabrina, Ahmad Saif S, Sotiropoulos Marios, Jena Raj, Cowburn Russell

机构信息

Department of Physics, University of Cambridge JJ Thomson Avenue Cambridge CB3 0HE UK

Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre Cambridge Biomedical Campus Cambridge CB2 0XZ UK.

出版信息

RSC Adv. 2020 Feb 25;10(14):8161-8171. doi: 10.1039/d0ra00164c. eCollection 2020 Feb 24.

DOI:10.1039/d0ra00164c
PMID:35558340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9092955/
Abstract

This study describes the use of highly versatile, lithographically defined magnetic microdiscs. Gold covered magnetic microdiscs are used in both radiosensitizing cancer cells, acting as intracellular emitters of secondary electrons during radiotherapy, and as well as inducing mechanical damage by exerting a mechanical torque when exposed to a rotating magnetic field. This study reveals that lithographically defined microdiscs with a uniform size of 2 microns in diameter highly increase the DNA damage and reduce the glioblastoma colony formation potential compared to conventional radiation therapy. Furthermore, the addition of mechanical disruption mediated by the magnetic component of the discs increased the efficiency of brain cancer cell killing.

摘要

本研究描述了高度通用的光刻定义磁性微盘的应用。镀金磁性微盘用于使癌细胞对放疗增敏，在放疗期间作为二次电子的细胞内发射体，并且在暴露于旋转磁场时通过施加机械扭矩来诱导机械损伤。该研究表明，与传统放射治疗相比，直径均匀为2微米的光刻定义微盘显著增加了DNA损伤并降低了胶质母细胞瘤集落形成潜力。此外，由微盘的磁性成分介导的机械破坏的加入提高了脑癌细胞杀伤效率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e89/9092955/1cbc92df9cd1/d0ra00164c-f9.jpg
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