Adam E I
J Int Med Res. 1987 Mar-Apr;15(2):71-5. doi: 10.1177/030006058701500202.
A compound analgesic/anti-emetic formulation was significantly effective in reducing the severity of acute attacks of migraine, in a double-blind, randomized, crossover trial of 34 patients referred to a migraine clinic. The preparation contained paracetamol (acetaminophen) 500 mg, codeine phosphate 8 mg, buclizine hydrochloride 6.25 mg and dioctyl sodium sulphosuccinate 10 mg. The dosage was two tablets taken as early as possible in the acute attack. No specific factors could be identified which influenced response to treatment. Patients with a long history of migraine (more than 10 years) responded as well as those with a recent onset of the condition.
在一项针对34名转诊至偏头痛诊所患者的双盲、随机、交叉试验中，一种复方镇痛/止吐制剂在减轻偏头痛急性发作的严重程度方面具有显著疗效。该制剂含有对乙酰氨基酚500毫克、磷酸可待因8毫克、盐酸氯苯丁嗪6.25毫克和二辛基磺基琥珀酸钠10毫克。剂量为在急性发作时尽早服用两片。未发现有影响治疗反应的特定因素。偏头痛病史长（超过10年）的患者与近期发病的患者反应相同。
