Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via Santa Maria di Costantinopoli 16, 80138 Naples, Italy.
Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 6, 80131 Naples, Italy.
Int J Mol Sci. 2022 Apr 19;23(9):4501. doi: 10.3390/ijms23094501.
The most frequent retinal diseases, such as diabetic retinopathy, age-related macular degeneration and posterior uveitis, are underlined by oxidative stress or aging-induced retinal inflammation, which contributes to vision impairing or loss. Resolution of inflammation is emerging as a critical phase able to counteract the inflammatory process leading to the progression of retinal damage. Particularly, pro-resolving mediators (PMs) play a key role in the modulation of inflammatory exudates and could be considered a new target to be investigated in different inflammatory-autoimmune pathologies. Here, we highlight the most recent studies concerning the role of the main PMs (lipoxins, resolvins, prtectins, maresins and annexins) in retinal inflammation, in order to collect the best evidence in the field of inflammatory retinal damage resolution and to propose novel pharmacological approaches in the management of the most common retinal diseases.
最常见的视网膜疾病，如糖尿病视网膜病变、年龄相关性黄斑变性和后葡萄膜炎，都与氧化应激或衰老引起的视网膜炎症有关，这会导致视力受损或丧失。炎症的消退正成为一个关键阶段，能够对抗导致视网膜损伤进展的炎症过程。特别是，促解决介质（PMs）在调节炎症渗出物方面起着关键作用，可被视为不同炎症自身免疫性疾病中需要研究的新靶点。在这里，我们重点介绍了关于主要 PMs（脂氧素、消退素、保护素、maresins 和膜联蛋白）在视网膜炎症中的作用的最新研究，以收集该领域炎症性视网膜损伤消退的最佳证据，并提出治疗最常见视网膜疾病的新的药理学方法。
