Division of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University, 1780 Gobara Hiro-oka, Shiojiri 399-0781, Nagano, Japan.
Department of Biochemistry, Matsumoto Dental University, 1780 Gobara Hiro-oka, Shiojiri 399-0781, Nagano, Japan.
Int J Mol Sci. 2022 Apr 28;23(9):4895. doi: 10.3390/ijms23094895.
Sclerostin is secreted from osteocytes, binds to the Wnt co-receptor Lrp5/6, and affects the interaction between Wnt ligands and Lrp5/6, which inhibits Wnt/β-catenin signals and suppresses bone formation. Sclerostin plays an important role in the preservation of bone mass by functioning as a negative regulator of bone formation. A sclerostin deficiency causes sclerosteosis, which is characterized by an excess bone mass with enhanced bone formation in humans and mice. The expression of sclerostin is positively and negatively regulated by many factors, which also govern bone metabolism. Positive and negative regulators of sclerostin expression and their effects are introduced and discussed herein based on recent and previous findings, including our research.
骨硬化蛋白由骨细胞分泌，与 Wnt 共受体 Lrp5/6 结合，并影响 Wnt 配体与 Lrp5/6 的相互作用，从而抑制 Wnt/β-连环蛋白信号通路，抑制骨形成。骨硬化蛋白作为骨形成的负调节剂，在维持骨量方面发挥着重要作用。骨硬化蛋白缺乏导致硬骨生成症，其特征是人类和小鼠的骨量过多，骨形成增强。骨硬化蛋白的表达受到许多因素的正向和负向调控，这些因素也控制着骨代谢。基于最近和以前的研究结果，包括我们的研究，本文介绍并讨论了骨硬化蛋白表达的正、负调节剂及其作用。
