Seeneevassen Lornella, Dubus Pierre, Gronnier Caroline, Varon Christine
BRIC (BoRdeaux Institute of onCology), UMR1312, INSERM, University of Bordeaux, F-33000 Bordeaux, France.
Department of Histology and Pathology, CHU Bordeaux, F-33000 Bordeaux, France.
Cancers (Basel). 2022 May 3;14(9):2282. doi: 10.3390/cancers14092282.
The Hippo pathway is one of the most important ones in mammals. Its key functions in cell proliferation, tissue growth, repair, and homeostasis make it the most crucial one to be controlled. Many means have been deployed for its regulation, since this pathway is not only composed of core regulatory components, but it also communicates with and regulates various other pathways, making this signalisation even more complex. Its role in cancer has been studied more and more over the past few years, and it presents YAP/TAZ as the major oncogenic actors. In this review, we relate how vital this pathway is for different organs, and how regulatory mechanisms have been bypassed to lead to cancerous states. Most studies present an upregulation status of YAP/TAZ, and urge the need to target them. A focus is made here on gastric carcinogenesis, its main dysregulations, and the major strategies adopted and tested to counteract Hippo pathway disbalance in this disease. Hippo pathway targeting can be achieved by various means, which are described in this review. Many studies have tested different potential molecules, which are detailed hereby. Though not all tested in gastric cancer, they could represent a real interest.
河马通路是哺乳动物中最重要的通路之一。它在细胞增殖、组织生长、修复和体内平衡中的关键功能使其成为最需要调控的通路。由于该通路不仅由核心调控成分组成，还与其他各种通路相互作用并进行调控，使得这种信号传导更加复杂，因此人们已经采用了多种手段对其进行调控。在过去几年中，人们对其在癌症中的作用研究得越来越多，并且发现YAP/TAZ是主要的致癌因子。在这篇综述中，我们阐述了该通路对不同器官的重要性，以及调控机制是如何被绕过从而导致癌症状态的。大多数研究表明YAP/TAZ处于上调状态，并强调了靶向作用于它们的必要性。本文重点关注胃癌发生、其主要的失调情况，以及为对抗该疾病中河马通路失衡而采用和测试的主要策略。靶向河马通路可以通过多种方式实现，本文对此进行了描述。许多研究已经测试了不同的潜在分子，在此详细介绍。尽管并非所有这些分子都在胃癌中进行了测试，但它们可能具有实际意义。
