tau：人群中的一个阶段。
Tau: a phase in the crowd.
机构信息
Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
出版信息
EMBO J. 2022 Jun 1;41(11):e111425. doi: 10.15252/embj.2022111425. Epub 2022 May 17.
Abstract
From the management of microtubules to the production of pathological species: liquid-liquid phase separation may tune the behavior of the protein tau in health and neurodegenerative disease. In this issue of The EMBO Journal, Hochmair et al (2022) demystify important aspects of tau condensate compilation.
摘要
从微管的管理到病理性物种的产生
液-液相分离可能会调节蛋白质 tau 在健康和神经退行性疾病中的行为。在本期《EMBO 杂志》中，Hochmair 等人（2022）揭开了 tau 凝聚物组装的重要方面的神秘面纱。
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Evidence for widespread cytoplasmic structuring into mesoscale condensates.
Nat Cell Biol. 2024 Mar;26(3):346-352. doi: 10.1038/s41556-024-01363-5. Epub 2024 Feb 29.
2
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EMBO J. 2022 Jun 1;41(11):e108882. doi: 10.15252/embj.2021108882. Epub 2022 Mar 17.
3
Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope.
BMC Biol. 2021 Sep 9;19(1):199. doi: 10.1186/s12915-021-01132-y.
4
Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease.
Acta Neuropathol Commun. 2021 Jan 28;9(1):18. doi: 10.1186/s40478-020-01117-y.
5
Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force.
Dev Cell. 2020 Oct 12;55(1):45-68. doi: 10.1016/j.devcel.2020.09.014.
6
The Hitchhiker's Guide to Nucleocytoplasmic Trafficking in Neurodegeneration.
Neurochem Res. 2020 Jun;45(6):1306-1327. doi: 10.1007/s11064-020-02989-1. Epub 2020 Feb 21.
7
Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review.
JAMA Neurol. 2019 Jan 1;76(1):101-108. doi: 10.1001/jamaneurol.2018.2505.
8
Tau protein liquid-liquid phase separation can initiate tau aggregation.
EMBO J. 2018 Apr 3;37(7). doi: 10.15252/embj.201798049. Epub 2018 Feb 22.
9
Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase.
Cell Rep. 2017 Sep 5;20(10):2304-2312. doi: 10.1016/j.celrep.2017.08.042.
10
RNA stores tau reversibly in complex coacervates.
PLoS Biol. 2017 Jul 6;15(7):e2002183. doi: 10.1371/journal.pbio.2002183. eCollection 2017 Jul.
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