Department of Urology, Saint James's Hospital, Dublin, Ireland
Department of Surgery, Trinity College Dublin School of Medicine, Dublin, Ireland.
BMJ Case Rep. 2022 May 17;15(5):e248718. doi: 10.1136/bcr-2021-248718.
A man in his 70s was referred to plastic surgery with a suspected foreign body in the pulp of his right index finger. An excisional biopsy was performed for a presumed foreign body granuloma. Histology revealed metastatic renal cell carcinoma (mRCC). CT imaging demonstrated a 7.4 cm heterogeneous mass arising from the upper pole of the left kidney consistent with primary renal malignancy, in addition to a 9 mm lung nodule. He underwent an uncomplicated left laparoscopic cytoreductive nephrectomy and made a satisfactory recovery. To our knowledge, this is the first reported case of primary mRCC presenting with digital soft tissue metastasis. Cytoreductive nephrectomy with metastasectomy is the preferred management for mRCC where feasible. For unfavourable mRCC cases, first-line systemic therapy is indicated. Adjuvant systemic therapy in mRCC is currently limited to clinical trials, though promising data emerging on the use of pembrolizumab may herald a future shift in practice.
一位 70 多岁的男性因右食指牙髓内疑似异物而被转至整形外科。进行了切除活检以明确是否为异物肉芽肿。组织学检查显示转移性肾细胞癌(mRCC)。CT 成像显示左肾上部有一个 7.4cm 的异质性肿块,符合原发性肾恶性肿瘤,此外还有一个 9mm 的肺结节。他接受了简单的左侧腹腔镜细胞减灭性肾切除术,恢复良好。据我们所知,这是首例报告的原发性 mRCC 表现为数字软组织转移的病例。对于可行的 mRCC,细胞减灭性肾切除术联合转移灶切除术是首选治疗方法。对于预后不良的 mRCC 病例,一线系统治疗是指征。mRCC 的辅助系统治疗目前仅限于临床试验,但关于 pembrolizumab 使用的有希望的数据可能预示着未来实践的转变。