Zerbe C A, Nachreiner R F, Dunstan R W, Dalley J B
J Am Vet Med Assoc. 1987 Mar 1;190(5):559-63.
A diabetic cat with hyperadrenocorticism had polydipsia, polyuria, ventral abdominal alopecia, thin dry skin, and a pendulous abdomen. Results of laboratory testing indicated persistent resting hypercortisolemia, hyperresponsiveness of the adrenal glands (increased cortisol concentration) to ACTH gel, and no suppression of cortisol concentrations after administration of dexamethasone at 0.01 or 1.0 mg/kg of body weight. Necropsy revealed a pituitary gland tumor, bilateral adrenal hyperplasia, hepatic neoplasia, and demodicosis. Adrenal gland function was concurrently assessed in 2 cats with diabetes mellitus. One cat had resting hypercortisolemia, and both had hyperresponsiveness to ACTH gel (increased cortisol concentration) at one hour. After administration of dexamethasone (0.01 and 1.0 mg/kg), the diabetic cats appeared to have normal suppression of cortisol concentrations. The effects of mitotane were investigated in 4 clinically normal cats. Adrenocortical suppression of cortisol production occurred in 2 of 4 cats after dosages of 25, 37, and 50 mg/kg. Three cats remained clinically normal throughout the study. One cat experienced vomiting, diarrhea, and anorexia.
一只患有肾上腺皮质功能亢进的糖尿病猫有多饮、多尿、腹部腹侧脱毛、皮肤薄而干燥以及腹部下垂的症状。实验室检测结果显示持续静息性高皮质醇血症、肾上腺对促肾上腺皮质激素凝胶反应性增强（皮质醇浓度升高），且在给予0.01或1.0mg/kg体重的地塞米松后皮质醇浓度未被抑制。尸检发现垂体肿瘤、双侧肾上腺增生、肝脏肿瘤和蠕形螨病。同时对2只糖尿病猫的肾上腺功能进行了评估。一只猫有静息性高皮质醇血症，两只猫在一小时时对促肾上腺皮质激素凝胶均有反应性增强（皮质醇浓度升高）。给予地塞米松（0.01和1.0mg/kg）后，糖尿病猫的皮质醇浓度似乎有正常抑制。在4只临床正常的猫中研究了米托坦的作用。在给予25、37和50mg/kg剂量后，4只猫中有2只出现肾上腺皮质对皮质醇产生的抑制。在整个研究过程中，3只猫临床正常。一只猫出现呕吐、腹泻和厌食。
