伴有广泛“腰带状”钙化的治疗抵抗性皮肌炎。
Therapy-resistant dermatomyositis with extensive 'lumbar belt' calcinosis.
机构信息
Dermatology, Hospital Universitario Virgen del Rocio, Seville, Spain.
Division of Pulmonary, Allergy and Sleep Medicine, Department of Medicine, Mayo Clinic, Jacksonville, Florida, USA
出版信息
BMJ Case Rep. 2022 May 18;15(5):e249110. doi: 10.1136/bcr-2022-249110.
Calcinosis cutis (CC) is the umbrella term for calcium salt deposition on skin and subcutaneous tissue. We present a unique case of CC associated with anti-Mi2-positive dermatomyositis, having a distinctive distribution of subcutaneous calcifications appearing as a 'lumbar belt'. Treatment of CC remains challenging for clinicians due to a lack of high-quality evidence. Corticosteroids, methotrexate, bisphosphonates, intravenous immunoglobulin replacement, rituximab and sodium thiosulfate failed to halt calcinosis progression in this case. Newer therapies, such as Janus kinase inhibitors, should be considered.
皮肤钙质沉着症（CC）是指钙盐在皮肤和皮下组织沉积的总称。我们报告了一例与抗 Mi2 阳性皮肌炎相关的 CC 病例，其特征性的皮下钙化分布呈“腰带状”。由于缺乏高质量的证据，CC 的治疗仍然是临床医生面临的挑战。在本例中，皮质类固醇、甲氨蝶呤、双膦酸盐、静脉注射免疫球蛋白替代物、利妥昔单抗和硫代硫酸钠均未能阻止钙质沉着症的进展。应考虑使用新型治疗药物，如 Janus 激酶抑制剂。
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