[不同治疗方式治疗上颌骨成釉细胞瘤:92例回顾性分析]

[Treatment of maxillary ameloblastoma with different modalities: a retrospective analysis of 92 cases].

作者信息

Luo Hao, Yuan Zhuang, Wu Kai-Liu, He Jie, Meng Jian

机构信息

School of Stomatology, Xuzhou Medical University. Xuzhou 221000, Jiangsu Province, China. E-mail:

出版信息

Shanghai Kou Qiang Yi Xue. 2022 Feb;31(1):71-74.

DOI:
Abstract

PURPOSE

To explore the appropriate surgical approach for each type of maxillary ameloblastoma.

METHODS

The clinical data of 92 patients with maxillary ameloblastoma were retrospectively analyzed. All patients were pathologically diagnosed, followed up for 3-8 years after surgery, maxillofacial CT and panoramic images were taken regularly to observe the surgical outcomes. SPSS 22.0 software package was used for data analysis.

RESULTS

The proportion of maxillary ameloblastoma in male and female patients was 3 to 1,with more male patients and the mean age was 45.77 years old. The total recurrence rate of 92 patients was 21.74%, among which unicystic ameloblastoma had no recurrence after different surgical procedures. Among 38 patients with typical maxillary ameloblastoma, 14 underwent curettage, 3 underwent decompression,16 underwent extended resection, 3 underwent subtotal maxillary resection, 1 underwent iliac bone transplantation after subtotal maxillary resection, and 1 underwent reconstruction with anterolateral thigh flap after subtotal maxillary resection. Among them, 18 had recurrence and 5 had canceration. Three patients with extrasseous/peripheral type underwent expanded resection and two underwent curettage,none of them had recurrence. One patient with metastasizing ameloblastoma recurred after extended resection.

CONCLUSIONS

Maxillary ameloblastoma with unicystic type should be completely removed with minimal trauma. The recurrence rate of maxillary ameloblastoma via simple curettage or extended resection is still relatively high, which may be due to the large tumor involvement scope of these patients and the failure of complete tumor removal by curettage. For external/peripheral ameloblastoma and metastatic ameloblastoma, the involved jaw bone should be removed as much as possible to prevent recurrence. For malignant transformation of ameloblastoma, the tumor and jaw bone should be dissected during the operation to reduce recurrence rate. The primary site, cervical lymph nodes and lungs should be closely followed after operation to detect early metastasis.

摘要

目的

探讨上颌骨成釉细胞瘤各类型的合适手术方式。

方法

回顾性分析92例上颌骨成釉细胞瘤患者的临床资料。所有患者均经病理诊断,术后随访3 - 8年,定期拍摄颌面CT及全景片观察手术效果。采用SPSS 22.0软件包进行数据分析。

结果

上颌骨成釉细胞瘤患者男女比例为3∶1,男性患者居多,平均年龄45.77岁。92例患者总复发率为21.74%,其中单囊性成釉细胞瘤经不同手术方式后无复发。38例典型上颌骨成釉细胞瘤患者中,14例行刮除术,3例行减压术,16例行扩大切除术,3例行上颌骨次全切除术,1例上颌骨次全切除术后行髂骨移植,1例上颌骨次全切除术后行股前外侧皮瓣修复。其中18例复发,5例恶变。3例骨外/外周型患者行扩大切除术,2例行刮除术,均无复发。1例转移性成釉细胞瘤患者扩大切除术后复发。

结论

单囊性上颌骨成釉细胞瘤应在创伤最小的情况下完整切除。单纯刮除术或扩大切除术治疗上颌骨成釉细胞瘤的复发率仍相对较高,这可能是由于这些患者肿瘤累及范围大且刮除术未能完全切除肿瘤。对于外周型成釉细胞瘤和转移性成釉细胞瘤,应尽可能切除受累颌骨以防止复发。对于成釉细胞瘤恶变,术中应切除肿瘤及颌骨以降低复发率。术后应密切随访原发部位、颈部淋巴结及肺部,以早期发现转移。

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