Department of Neurology, Beni-Suef University, Beni-Suef, Egypt.
Department of Anaesthesia, Surgical ICU and Pain management, Beni-Suef University, Beni-Suef, Egypt.
Pain Med. 2022 Dec 1;23(12):2061-2072. doi: 10.1093/pm/pnac076.
The aim of this work was to explore the expression of miR-320a level in fibromyalgia patients in comparison to healthy controls, and to clarify its impact on the severity of symptoms and the cerebral processing of pain assessed by middle latency somatosensory evoked potentials (SSEPs).
Case-control study.
Rheumatology and Neurology outpatient clinics.
Seventy-four fibromyalgia patients and seventy-four normal healthy controls.
The included patients were subjected to detailed history taking, assessment of severity of fibromyalgia symptoms using the Fibromyalgia Impact Questionnaire Revised (FIQR), assessment of pain intensity using the Neuropathic Pain Symptom Inventory (NPSI), measurement of the serum level of miR-320a in addition to of measurement peak latencies and amplitudes of middle latency SSEPs.
Fibromyalgia patients had significantly higher micro-RNA-320a levels (0.907 ± 0.022) in comparison to controls (0.874 ± 0.015) (P-value < .001). The mean values of micro-RNA-320a levels were significantly higher in fibromyalgia patients with insomnia, chronic fatigue syndrome, persistent depressive disorder, and primary headache disorder than those without (P-value = .024, <.001, .006, .036 respectively). There were statistically significant positive correlations between micro-RNA-320a levels, and disease duration, FIQR, and NPSI total scores (P-value <0.001, 0.003, 0.002 respectively). There were no statistically significant correlations between micro-RNA-320a levels and middle latency SSEPs.
Micro-RNA-320a level is significantly upregulated in fibromyalgia patient. It has a crucial impact on the severity of symptoms but not related to the cerebral processing of pain.
本研究旨在探讨 miR-320a 水平在纤维肌痛患者中的表达，并分析其与健康对照组之间的差异，同时阐明其对症状严重程度的影响，以及对中潜伏期体感诱发电位（SSEP）评估的疼痛脑处理的影响。
病例对照研究。
风湿病学和神经病学门诊。
74 例纤维肌痛患者和 74 例健康对照组。
纳入的患者接受详细的病史询问、纤维肌痛影响问卷修订版（FIQR）评估症状严重程度、神经性疼痛症状量表（NPSI）评估疼痛强度、miR-320a 血清水平测量以及中潜伏期 SSEP 峰潜伏期和振幅测量。
纤维肌痛患者的 micro-RNA-320a 水平（0.907±0.022）明显高于对照组（0.874±0.015）（P<0.001）。伴有失眠、慢性疲劳综合征、持续性抑郁障碍和原发性头痛障碍的纤维肌痛患者的 micro-RNA-320a 水平均值明显高于无上述合并症的患者（P 值分别为=0.024、<0.001、0.006、0.036）。micro-RNA-320a 水平与疾病持续时间、FIQR 和 NPSI 总分呈显著正相关（P 值均<0.001、0.003、0.002）。micro-RNA-320a 水平与中潜伏期 SSEP 无显著相关性。
micro-RNA-320a 水平在纤维肌痛患者中显著上调。它对症状的严重程度有重要影响，但与疼痛的大脑处理无关。
