Wilson P, Snow P J
J Neurophysiol. 1987 Mar;57(3):803-18. doi: 10.1152/jn.1987.57.3.803.
The effect of acute and chronic section of the digital nerves of a single toe on the organization of low-threshold, mechanoreceptive fields of lumbosacral spinocervical tract (SCT) neurons has been studied in adult cats anesthetized with chloralose. The immediate effect of sectioning the digital nerves of a single toe is to produce a patch of dorsal horn in the medial region of the ipsilateral lumbosacral cord in which SCT neurons lack any peripheral receptive field when gentle hair movement or light touch of glabrous skin are used as stimuli. Other SCT neurons in the region may lose only part of their receptive fields. Between 30 and 70 days later most of the affected SCT neurons have established receptive fields. These are mainly on somatotopically inappropriate areas of skin medially and laterally adjacent to the denervated region. A small proportion of SCT neurons form discontinuous receptive fields. The relative somatotopic organization within the affected region remains unchanged. As there is no sign of regeneration of the sectioned nerves the new receptive fields must result from a central reorganization of excitatory inputs to SCT neurons. It is concluded that chronic peripheral nerve section affects the anatomical and physiological mechanisms underlying the formation of light touch receptive fields of dorsal horn neurons in the lumbosacral cord of the adult cat, but that the resulting reorganization of receptive fields is spatially restricted.
在使用水合氯醛麻醉的成年猫中，研究了单趾指神经的急性和慢性切断对腰骶部脊髓颈髓束（SCT）神经元低阈值机械感受野组织的影响。切断单趾指神经的即时效应是在同侧腰骶髓内侧区域产生一片背角区域，当使用轻柔的毛发移动或无毛皮肤的轻触作为刺激时，该区域的SCT神经元缺乏任何外周感受野。该区域的其他SCT神经元可能仅失去其部分感受野。30至70天后，大多数受影响的SCT神经元建立了感受野。这些感受野主要位于去神经支配区域内侧和外侧的皮肤躯体定位不适当区域。一小部分SCT神经元形成不连续的感受野。受影响区域内的相对躯体定位组织保持不变。由于切断的神经没有再生迹象，新的感受野必定是由SCT神经元兴奋性输入的中枢重组产生的。得出的结论是，慢性外周神经切断影响成年猫腰骶髓背角神经元轻触感受野形成的解剖学和生理学机制，但由此产生的感受野重组在空间上受到限制。
