Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
Eur J Med Res. 2022 May 23;27(1):70. doi: 10.1186/s40001-022-00694-z.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a pneumonia outbreak and was called 2019 novel coronavirus disease (COVID-19). COVID-19 emerged in December 2019 and now considered a pandemic. Zinc supplementation can reduce mortality in patients with severe pneumonia. This study aimed at meta-analysis of the results of related studies and evaluate the effect of zinc supplementation on COVID-19 mortality.
A systematic search has conducted for manuscripts through PUBMED/Medline and Google Scholar (Cochrane guideline has considered it as the gray literature) up to September 2021. This meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Guideline for evaluation of the effect zinc supplementation on COVID-19 mortality. Based on the heterogeneity a fixed-effect or random-effect model, the OR and 95% CI were used to assess the combined risk.
After assessment, five studies with 1506 participants in case and control groups were included in meta-analysis. The OR for one study was not estimable, and the pool OR was estimated for other studies with 1398 participants. The meta-analysis showed that zinc supplementation in cases led to a significant lower risk of mortality when it was compared with the control group; pooled OR (95% CI) was 0.57 [0.43, 0.77] (P < 0.001).
This meta-analysis has suggested that zinc supplementation is associated with a lower mortality rate in COVID-19 patients. Zinc supplementation could be considered as a simple way and cost benefit approach for reduction of mortality in COVID-19 patients.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是引起肺炎暴发的病原体，被称为 2019 年新型冠状病毒病（COVID-19）。COVID-19 于 2019 年 12 月出现，现被认为是一种大流行疾病。补锌可降低重症肺炎患者的死亡率。本研究旨在对相关研究结果进行荟萃分析，评估补锌对 COVID-19 死亡率的影响。
通过 PUBMED/Medline 和 Google Scholar（Cochrane 指南将其视为灰色文献）系统检索文献，检索时间截至 2021 年 9 月。本荟萃分析遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南，以评估补锌对 COVID-19 死亡率的影响。根据异质性，使用固定效应或随机效应模型，使用 OR 和 95%CI 来评估合并风险。
评估后，纳入了五项研究，共有 1506 名病例和对照组参与者进行荟萃分析。一项研究的 OR 无法估计，其他四项研究的 OR 则使用 1398 名参与者进行估计。荟萃分析表明，与对照组相比，补锌可显著降低病例组的死亡率；合并 OR（95%CI）为 0.57 [0.43, 0.77]（P<0.001）。
本荟萃分析表明，补锌与 COVID-19 患者的死亡率降低相关。补锌可被视为降低 COVID-19 患者死亡率的一种简单、具有成本效益的方法。
