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蛇伤致中毒行血液透析治疗的临床特点及疗效的数理分析

Clinical Characteristics and Mathematical Analysis of Curative Effect of Hemodialysis in Curing Poisoning Caused by Snakebite.

机构信息

Department of Emergency Medicine, Emergency Medicine Department of the 910th Hospital of JLSF, Quanzhou Fujian 362000, China.

Department of Emergency Medicine, Liuzhou Traditional Chinese Medical Hospital, Liuzhou Guangxi 530021, China.

出版信息

Scanning. 2022 May 6;2022:2312972. doi: 10.1155/2022/2312972. eCollection 2022.

Abstract

In order to explore the clinical characteristics of hemodialysis in curing poisoning from snakebites, a two-classification model of nuclear logistic neural network based on restricted Boltzmann machine is proposed. The model combines kernel logistic regression with artificial neural networks, enabling the model to both learn autonomously and handle linearly inseparable problems. The network first performs feature learning through unsupervised training of restricted Boltzmann machines and obtains the initial values of the parameters to be identified, which reduces the influence of the randomness of the initial parameters. The variable universe learning rate with scaling factor is used to learn the parameters to be identified, and the model convergence speed is improved by dynamic adjustment of the learning rate. Experimental results show the following: Compared with before treatment, patient's activated partial thromboplastin time (APTT) after treatment and the prothrombin time (PT) level decrease, fibrinogen (FIB) levels are elevated, aspartate transferase (AST) and creatine kinase isoenzyme (CK-MB) level decreased, and the differences were statistically significant ( < 0.05). It is proved that continuous hemodiafiltration combined with plasma exchange treatment can effectively improve the blood coagulation index and myocardial index of severe snakebite poisoning patients.

摘要

为了探索血液透析治疗蛇伤中毒的临床特点,提出了一种基于限制玻尔兹曼机的核逻辑神经网络二分类模型。该模型将核逻辑回归与人工神经网络相结合,使模型既能自主学习,又能处理线性不可分问题。该网络首先通过受限玻尔兹曼机的无监督训练进行特征学习,获得待识别参数的初始值,从而减少初始参数随机性的影响。采用带比例因子的变论域学习率来学习待识别参数,通过动态调整学习率提高模型的收敛速度。实验结果表明:与治疗前相比,患者治疗后的活化部分凝血活酶时间(APTT)和凝血酶原时间(PT)水平降低,纤维蛋白原(FIB)水平升高,天冬氨酸转氨酶(AST)和肌酸激酶同工酶(CK-MB)水平降低,差异均有统计学意义(<0.05)。证明连续性血液透析滤过联合血浆置换治疗能有效改善重症蛇伤中毒患者的凝血指标和心肌指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6456/9106513/ac8a47e1068f/SCANNING2022-2312972.001.jpg

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