State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China.
Department of Medical Research, Key Laboratory of Environmental Sense Organ Stress and Health of the Ministry of Environmental Protection, PLA Strategic Support Force Medical Center, Beijing, P. R. China.
Int J Infect Dis. 2022 Sep;122:38-45. doi: 10.1016/j.ijid.2022.05.042. Epub 2022 May 20.
Selenium deficiency can be associated with increased susceptibility to some viral infections and even more severe diseases. In this study, we aimed to examine whether this association applies to severe fever with thrombocytopenia syndrome (SFTS).
An observational study was conducted based on the data of 13,305 human SFTS cases reported in mainland China from 2010 to 2020. The associations among incidence, case fatality rate of SFTS, and crop selenium concentration at the county level were explored. The selenium level in a cohort of patients with SFTS was tested, and its relationship with clinical outcomes was evaluated.
The association between selenium-deficient crops and the incidence rate of SFTS was confirmed by multivariate Poisson analysis, with an estimated incidence rate ratio (IRR, 95% confidence interval [CI]) of 4.549 (4.215-4.916) for moderate selenium-deficient counties and 16.002 (14.706-17.431) for severe selenium-deficient counties. In addition, a higher mortality rate was also observed in severe selenium-deficient counties with an IRR of 1.409 (95% CI: 1.061-1.909). A clinical study on 120 patients with SFTS showed an association between serum selenium deficiency and severe SFTS (odds ratio, OR: 2.94; 95% CI: 1.00-8.67) or fatal SFTS (OR: 7.55; 95% CI: 1.14-50.16).
Selenium deficiency is associated with increased susceptibility to SFTS and poor clinical outcomes.
硒缺乏与某些病毒感染的易感性增加甚至更严重的疾病有关。本研究旨在探讨这种关联是否适用于严重发热伴血小板减少综合征（SFTS）。
基于 2010 年至 2020 年中国大陆报告的 13305 例人类 SFTS 病例数据，进行了一项观察性研究。探讨了县级农作物硒浓度与 SFTS 发病率、病死率的关系。检测了一组 SFTS 患者的硒水平，并评估其与临床结局的关系。
多因素泊松分析证实了缺硒作物与 SFTS 发病率之间的关联，中度缺硒县的估计发病率比（IRR，95%置信区间[CI]）为 4.549（4.215-4.916），严重缺硒县为 16.002（14.706-17.431）。此外，严重缺硒县的死亡率也较高，IRR 为 1.409（95%CI：1.061-1.909）。对 120 例 SFTS 患者的临床研究表明，血清硒缺乏与严重 SFTS（比值比，OR：2.94；95%CI：1.00-8.67）或致命 SFTS（OR：7.55；95%CI：1.14-50.16）有关。
硒缺乏与 SFTS 的易感性增加和不良临床结局有关。
