Zhang Fomin, Kadierding Rena, Zhang Shihan, Yang Hua, Ren Libin, Ren Min, Ma Yue, Wang Le, Zhang Rui, Li Wenyu, Cong Hongliang, Zhang Yingyi
Thoracic Clinical College, 12610Tianjin Medical University, Tianjin, China.
Department of Cardiology, 499773Tianjin Chest Hospital, Tianjin, China.
Angiology. 2023 Mar;74(3):259-267. doi: 10.1177/00033197221104559. Epub 2022 May 27.
We conducted a longitudinal study (from February 2017 to July 2017) to explore whether the triglyceride glucose index (TyG) index has a prognostic value for major adverse cardiovascular events (MACE) among high-risk Chinese hypertensives. The study population were from 6 districts of Tianjin, China. Finally, a total of 2250 patients were enrolled in this 3.5 year cohort study. The patients were divided into two groups according to the cut-off value of the TyG index: Low-TyG group (n = 901, TyG ≤ 8.87), High-TyG group (n = 1349, TyG > 8.87). Univariate and multivariate Cox regression analyses were used to estimate the relationship between the TyG and MACE. In multivariate cox regression analyses, the hazard ratio (HR) (95% confidence interval (CI)) of the high-TyG group was 1.313 (1.010, 1.708) compared with the low-TyG group. In those with an age ≤65 years and male subgroups, the prediction value of TyG was higher, and the risk of occurrence of MACE greater after adjusting other risk factors. The TyG index is an indicator to predict the development of MACE in hypertensive patients.
我们进行了一项纵向研究(2017年2月至2017年7月),以探讨甘油三酯葡萄糖指数(TyG指数)在中国高危高血压患者中对主要不良心血管事件(MACE)是否具有预后价值。研究人群来自中国天津的6个区。最终,共有2250例患者纳入了这项为期3.5年的队列研究。根据TyG指数的临界值将患者分为两组:低TyG组(n = 901,TyG≤8.87),高TyG组(n = 1349,TyG> 8.87)。采用单因素和多因素Cox回归分析来评估TyG与MACE之间的关系。在多因素Cox回归分析中,与低TyG组相比,高TyG组的风险比(HR)(95%置信区间(CI))为1.313(1.010,1.708)。在年龄≤65岁的人群和男性亚组中,调整其他危险因素后,TyG的预测价值更高,发生MACE的风险更大。TyG指数是预测高血压患者发生MACE的一个指标。