Surette Fionna A, Butler Noah S
Department of Microbiology and Immunology, Immunology Graduate Program, University of Iowa, Iowa City, IA 52242, USA.
Pathogens. 2022 Apr 29;11(5):523. doi: 10.3390/pathogens11050523.
Protective immunity against blood-stage infection and the disease malaria depends on antibodies secreted from high-affinity B cells selected during the germinal center (GC) response. The induction and stability of the GC response require the activation and direct cell-cell communication between parasite-specific CD4 helper T cells and B cells. However, cytokines secreted by helper T cells, B cells, and multiple other innate and adaptive immune cells also contribute to regulating the magnitude and protective functions of GC-dependent humoral immune responses. Here, we briefly review emerging data supporting the finding that specific cytokines can exhibit temporally distinct and context-dependent influences on the induction and maintenance of antimalarial humoral immunity.
针对血液阶段感染和疟疾疾病的保护性免疫依赖于生发中心（GC）反应期间选择的高亲和力B细胞分泌的抗体。GC反应的诱导和稳定性需要寄生虫特异性CD4辅助性T细胞与B细胞之间的激活和直接细胞间通讯。然而，辅助性T细胞、B细胞以及多种其他先天和适应性免疫细胞分泌的细胞因子也有助于调节GC依赖性体液免疫反应的强度和保护功能。在这里，我们简要回顾新出现的数据，这些数据支持特定细胞因子可对抗疟体液免疫的诱导和维持表现出时间上不同且依赖于背景的影响这一发现。
