Han V K, D'Ercole A J, Lund P K
Science. 1987 Apr 10;236(4798):193-7. doi: 10.1126/science.3563497.
The somatomedins or insulin-like growth factors (IGFs) are synthesized in many organs and tissues, but the specific cells that synthesize them in vivo have not been defined. By in situ hybridization histochemistry, IGF I (somatomedin C) and IGF II messenger RNAs were localized to connective tissues or cells of mesenchymal origin in 14 organs and tissues from human fetuses. IGF messenger RNAs were localized to perisinusoidal cells of liver, to perichondrium of cartilage, to sclera of eye, and to connective tissue layers, sheaths, septa, and capsules of each organ and tissue. All of the hybridizing regions are comprised predominantly of fibroblasts or other cells of mesenchymal origin. Because these cells are widely distributed and anatomically integrated into tissues and organs, they are ideally located for production of IGFs, which may exert paracrine effects on nearby target cells.
生长调节素或胰岛素样生长因子（IGFs）在许多器官和组织中合成，但体内合成它们的特定细胞尚未明确。通过原位杂交组织化学方法，在人类胎儿的14个器官和组织中，IGF I（生长调节素C）和IGF II信使核糖核酸定位于间充质来源的结缔组织或细胞。IGF信使核糖核酸定位于肝脏的窦周细胞、软骨的软骨膜、眼睛的巩膜以及每个器官和组织的结缔组织层、鞘、隔膜和被膜。所有杂交区域主要由成纤维细胞或其他间充质来源的细胞组成。由于这些细胞广泛分布并在解剖学上整合到组织和器官中，它们处于产生IGFs的理想位置，IGFs可能对附近的靶细胞发挥旁分泌作用。
