MAP3K 家族综述及其与多种癌症类型患者生存结局的相关性。

MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types.

机构信息

Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Department of Pharmacological Sciences, Division of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15218, USA.

出版信息

Front Biosci (Landmark Ed). 2022 May 23;27(5):167. doi: 10.31083/j.fbl2705167.

DOI:10.31083/j.fbl2705167

PMID:35638434

Abstract

The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we discuss members of the MAP3K family and correlate their mRNA expression levels to patient survival outcomes in different cancers. Furthermore, we highlight the importance of studying the MAP3K family due to their important roles in the larger, overall MAPK pathway, relationships with cancer progression, and the understudied status of these kinases.

摘要

丝裂原活化蛋白激酶（MAPK）途径在细胞信号转导中普遍存在，对正常的生物学功能至关重要。该信号轴的中断可导致疾病，如癌症的发展。在这篇综述中，我们讨论了 MAP3K 家族的成员，并将其 mRNA 表达水平与不同癌症患者的生存结果相关联。此外，我们强调了研究 MAP3K 家族的重要性，因为它们在更大的 MAPK 途径中起着重要作用，与癌症进展有关，以及这些激酶的研究不足。