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本文引用的文献

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World J Gastroenterol. 2020 Nov 7;26(41):6475-6487. doi: 10.3748/wjg.v26.i41.6475.
2
Effect of anticoagulants on the risk of delayed bleeding after colorectal endoscopic submucosal dissection.抗凝剂对结直肠内镜黏膜下剥离术后迟发性出血风险的影响。
Endosc Int Open. 2020 Nov;8(11):E1654-E1663. doi: 10.1055/a-1244-2097. Epub 2020 Oct 22.
3
The risks and characteristics of the delayed bleeding after endoscopic submucosal dissection for early gastric carcinoma in cases with anticoagulants.抗凝剂使用情况下早期胃癌内镜黏膜下剥离术后迟发性出血的风险及特征
Scand J Gastroenterol. 2020 Oct;55(10):1253-1260. doi: 10.1080/00365521.2020.1817542. Epub 2020 Sep 14.
4
Effect of Vonoprazan on Delayed Bleeding after Endoscopic Submucosal Dissection for Gastric Neoplasia among Antithrombotic Drug Users: A Single-Center, Single-Arm Prospective Observational Case Control Study.抗血栓药物使用者行内镜黏膜下剥离术治疗胃肿瘤后延迟出血的 Vonoprazan 治疗效果:一项单中心、单臂前瞻性观察性病例对照研究。
Acta Med Okayama. 2020 Jun;74(3):245-250. doi: 10.18926/AMO/59958.
5
Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score.早期胃癌内镜黏膜下剥离术后出血预测模型:BEST-J 评分。
Gut. 2021 Mar;70(3):476-484. doi: 10.1136/gutjnl-2019-319926. Epub 2020 Jun 4.
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Endosc Int Open. 2019 Nov;7(11):E1542-E1548. doi: 10.1055/a-1007-1694. Epub 2019 Nov 11.
7
Japan Gastroenterological Endoscopy Society guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection.日本肠胃病学会结直肠内镜黏膜下剥离/内镜黏膜切除术指南。
Dig Endosc. 2020 Jan;32(2):219-239. doi: 10.1111/den.13545. Epub 2019 Dec 27.
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The effect of anticoagulants on delayed bleeding after colorectal endoscopic submucosal dissection.抗凝剂对结直肠内镜黏膜下剥离术后迟发性出血的影响。
Surg Endosc. 2020 Aug;34(8):3330-3337. doi: 10.1007/s00464-019-07101-5. Epub 2019 Sep 3.
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Dig Dis Sci. 2020 Feb;65(2):557-564. doi: 10.1007/s10620-019-05776-3. Epub 2019 Aug 7.
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Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy.连续低剂量阿司匹林用于双联抗血小板治疗患者行胃内镜黏膜下剥离术的可行性。
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[早期消化道癌内镜黏膜下剥离术后迟发性出血的研究进展]

[Research Progress in Delayed Bleeding after Endoscopic Submucosal Dissection of Early-Stage Gastrointestinal Cancer].

作者信息

Zhu Rui, Ma Cui-Yun, Min Min

机构信息

Department of Gastroenterology, Fifth Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 May;53(3):381-385. doi: 10.12182/20220560503.

DOI:10.12182/20220560503
PMID:35642142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10409415/
Abstract

Endoscopic submucosal dissection (ESD) has been widely used in the clinical treatment of early-stage and precancerous lesions of the digestive tract. Compared with traditional open surgery, the procedure has a number of advantages, including low postprocedural recurrence rate, the location and scope of lesions not posing much restrictions on the procedure, and quick patients recovery afterwards. The procedure has hence become one of the minimally-invasive procedures commonly performed with gastrointestinal endoscope. However, due to the influence of various factors, complications such as intraoperative and postoperative bleeding, perforation, electrocoagulation syndrome and lumen stenosis may occur. Delayed postoperative bleeding, in particular, may induce cardiovascular and other related diseases due to the insidious nature of its onset, resulting in serious consequences. It is critically important for the further development of ESD that we should acquire thorough understanding and mastery of the relevant influencing factors and preventive measures of delayed bleeding after ESD of early-stage gastrointestinal cancer. We herein summarized and discussed the latest research findings in the preventative and treatment measures.

摘要

内镜黏膜下剥离术(ESD)已广泛应用于消化道早期及癌前病变的临床治疗。与传统开放手术相比,该手术具有诸多优势,包括术后复发率低、病变的位置和范围对手术限制不大以及患者术后恢复快等。因此,该手术已成为胃肠内镜常见的微创手术之一。然而,由于各种因素的影响,可能会出现术中及术后出血、穿孔、电凝综合征和管腔狭窄等并发症。特别是术后延迟出血,因其发病隐匿,可能诱发心血管等相关疾病,导致严重后果。深入了解和掌握早期胃肠道癌ESD术后延迟出血的相关影响因素及预防措施,对ESD的进一步发展至关重要。我们在此总结并讨论了预防和治疗措施的最新研究结果。