Lack of hepatic autophagy promotes severity of liver injury but not steatosis.
作者信息
Ding Wen-Xing, Ni Hong-Min, Waguri Satoshi, Komatsu Masaaki
机构信息
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
出版信息
J Hepatol. 2022 Nov;77(5):1458-1459. doi: 10.1016/j.jhep.2022.05.015. Epub 2022 May 25.
Abstract
摘要
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Lack of hepatic autophagy promotes severity of liver injury but not steatosis.肝脏自噬的缺乏会加重肝损伤的严重程度，但不会加重脂肪变性。
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本文引用的文献
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Rare ATG7 genetic variants predispose patients to severe fatty liver disease.罕见的 ATG7 基因突变使患者易患严重的脂肪肝疾病。
J Hepatol. 2022 Sep;77(3):596-606. doi: 10.1016/j.jhep.2022.03.031. Epub 2022 Apr 9.
2
Loss of autophagy impairs physiological steatosis by accumulation of NCoR1.自噬缺失通过 NCoR1 的积累损害生理性脂肪变性。
Life Sci Alliance. 2019 Dec 26;3(1). doi: 10.26508/lsa.201900513. Print 2020 Jan.
3
Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation.肝特异性 Atg5 缺陷型小鼠肝脏中，禁食诱导的适应性脂滴生物发生受损是由持续的核因子样 2 激活介导的。
Am J Pathol. 2018 Aug;188(8):1833-1846. doi: 10.1016/j.ajpath.2018.04.015. Epub 2018 May 25.
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DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.依赖二酰甘油酰基转移酶1的脂滴生物合成在饥饿诱导的自噬过程中保护线粒体功能。
Dev Cell. 2017 Jul 10;42(1):9-21.e5. doi: 10.1016/j.devcel.2017.06.003.
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Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.在肝脏自噬缺陷的小鼠中，Nrf2促进纤维化发展和肿瘤发生。
J Hepatol. 2014 Sep;61(3):617-25. doi: 10.1016/j.jhep.2014.04.043. Epub 2014 May 9.
6
Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD.肝脏中FIP200缺失导致的自噬缺陷使非酒精性脂肪性肝病（NAFLD）中的脂肪变性与肝损伤脱钩。
Mol Endocrinol. 2013 Oct;27(10):1643-54. doi: 10.1210/me.2013-1153. Epub 2013 Aug 19.
7
Autophagy-deficient mice develop multiple liver tumors.自噬缺陷小鼠会发展出多种肝脏肿瘤。
Genes Dev. 2011 Apr 15;25(8):795-800. doi: 10.1101/gad.2016211.
8
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.肥胖导致的肝脏自噬缺陷会促进内质网应激，并引起胰岛素抵抗。
Cell Metab. 2010 Jun 9;11(6):467-78. doi: 10.1016/j.cmet.2010.04.005.
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Autophagy regulates lipid metabolism.自噬调节脂质代谢。
Nature. 2009 Apr 30;458(7242):1131-5. doi: 10.1038/nature07976. Epub 2009 Apr 1.
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