[阿尔及利亚非透析依赖型慢性肾脏病和血液透析患者的营养不良、绝对铁缺乏和功能性缺铁性贫血患病率]

[Prevalence of malnutrition and absolute and functional iron deficiency anemia in nondialysis-dependent chronic kidney disease and hemodialysis Algerian patients].

作者信息

Laras Hayat, Haddoum Farid, Baghdali Feriel-Yasmine, Gagi Nadia, Koceir El Hadj Ahmed, Bitam Arezki

机构信息

Département de biologie et physiologie des organismes (BPO), laboratoire de bioénergétique et métabolisme intermédiaire, Faculté des Sciences Biologiques, université des sciences et de la technologie Houari Boumediene (USTHB), Alger, Algérie; Département de médecine, faculté des sciences de la santé, laboratoire risque cardiovasculaire en néphrologie et transplantation, université d'Alger 1, Alger, Algérie.

Département de médecine, faculté des sciences de la santé, laboratoire risque cardiovasculaire en néphrologie et transplantation, université d'Alger 1, Alger, Algérie; Service de néphrologie, hémodialyse et transplantation, Centre Hospitalier Universitaire Mustapha Pacha, Alger, Algérie.

出版信息

Nephrol Ther. 2022 Jul;18(4):237-246. doi: 10.1016/j.nephro.2022.03.001. Epub 2022 May 27.

DOI:10.1016/j.nephro.2022.03.001

PMID:35644772

Abstract

UNLABELLED

In chronic kidney disease, anemia and malnutrition coupled with inflammation as malnutrition-inflammation complex syndrom are common and considered as morbidity-mortality factors. The link between these two factors has been described at length in the literature highlighting an association of malnutrition with iron deficiency considered itself as one of the causes of anemia in chronic kidney disease (non-dialysis and hemodialysis). Our study aims to know the prevalence of these two factors in a population of chronic kidney disease (non-dialysis and hemodialysis) of Algiers and to highlight the possible associations between them.

PATIENTS AND METHODS

This is a multicentre, cross-sectional and descriptive study carried out over a period of 6months (August 2018 to January 2019). Anemia and malnutrition were assessed by various biological and clinical tools such as the malnutrition inflammation score and the International Society of Renal Nutrition and Metabolism criteria. Statistical tests were performed on the R studio software, considering P<0.05 as a statistically significant value.

RESULTS

Two hundred and nine patients on chronic kidney disease were included (90 non dialysis and 119 hemodialysis). The median age was 70 (IQR=16) for non dialysis and 56 (IQR=16.5) for hemodialysis. The prevalence of anemia was 66.66% (n=60) in non dialysis and 70.58% (n=84) in hemodialysis. Absolute iron deficiency anemia was higher in non dialysis (48.33%; n=29) while functional iron deficiency anemia was higher in hemodialysis (34.52%; n=29). The prevalence of malnutrition by malnutrition inflammation score was relatively low. Only functional iron deficiency anemia was associated with malnutrition.

CONCLUSION

The prevalence of anemia was higher in Algerian chronic kidney disease (non-dialysis and hemodialysis) unlike malnutrition which remains associated with functional iron deficiency anemia.

摘要

未标注

在慢性肾脏病中，贫血、营养不良以及炎症共同构成的营养不良 - 炎症复合综合征很常见，并被视为发病和死亡的因素。这两个因素之间的联系在文献中已有详细描述，强调了营养不良与缺铁之间的关联，而缺铁本身被认为是慢性肾脏病（非透析和血液透析）贫血的原因之一。我们的研究旨在了解阿尔及尔慢性肾脏病（非透析和血液透析）人群中这两个因素的患病率，并突出它们之间可能存在的关联。

患者与方法

这是一项多中心、横断面描述性研究，为期6个月（2018年8月至2019年1月）。通过多种生物学和临床工具评估贫血和营养不良，如营养不良炎症评分以及国际肾脏营养与代谢学会标准。在R studio软件上进行统计检验，将P<0.05视为具有统计学意义的值。

结果

纳入了209例慢性肾脏病患者（90例非透析患者和119例血液透析患者）。非透析患者的中位年龄为70岁（四分位间距=16），血液透析患者为56岁（四分位间距=16.5）。非透析患者中贫血患病率为66.66%（n = 60），血液透析患者中为70.58%（n = 84）。非透析患者中绝对缺铁性贫血更高（48.33%；n = 29），而血液透析患者中功能性缺铁性贫血更高（34.52%；n = 29）。根据营养不良炎症评分得出的营养不良患病率相对较低。只有功能性缺铁性贫血与营养不良相关。