Department of Respiratory Medicine, National Hospital Organization Minami-Kyoto Hospital, Kyoto, Japan.
Department of Respiratory Medicine, National Hospital Organization Minami-Kyoto Hospital, Kyoto, Japan.
Respir Investig. 2022 Sep;60(5):658-666. doi: 10.1016/j.resinv.2022.05.002. Epub 2022 May 26.
The effects of exercise training using both high fraction of inspired oxygen (FO) and high flow oxygen delivered through a high-flow nasal cannula (HFNC) on exercise capacity in patients with chronic respiratory failure (CRF) receiving long-term oxygen therapy (LTOT) are unknown.
In this randomized study, 32 patients with CRF receiving LTOT were assigned to undergo 4 weeks of exercise training on a cycle ergometer using an HFNC (flow: 50 L/min) with a FO of 1.0 (HFNC group; n = 16) or ordinary supplemental oxygen via a nasal cannula (flow: 6 L/min) (oxygen group; n = 16). A 6-min walking test and a constant-load test were performed before and after 4 weeks of exercise training.
Following 4 weeks of exercise training, change in the 6-min walking distance was significantly greater in the HFNC than in the oxygen group (55.2 ± 69.6 m vs. -0.5 ± 87.3 m; p = 0.04). However, there was no significant difference between the two groups in the degree of improvement in the duration of the constant-load exercise test after exercise training.
Considering the effect on daily activities (e.g., walking), exercise training using both high FO and high flow through an HFNC is a potentially superior exercise training modality for patients with CRF receiving LTOT. Clinical Trial Registration - http://www.
gov. Unique identifier: NCT02804243.
使用高吸氧分数（FO）和高流量通过高流量鼻导管（HFNC）输送的氧气进行运动训练对接受长期氧疗（LTOT）的慢性呼吸衰竭（CRF）患者的运动能力的影响尚不清楚。
在这项随机研究中，32 名接受 LTOT 的 CRF 患者被分配到使用 HFNC（流量：50 L/min）进行 4 周的自行车测力计运动训练，FO 为 1.0（HFNC 组；n = 16）或通过鼻导管（流量：6 L/min）进行普通补充氧气（氧气组；n = 16）。在 4 周的运动训练前后进行 6 分钟步行测试和恒负荷测试。
经过 4 周的运动训练，HFNC 组的 6 分钟步行距离变化明显大于氧气组（55.2 ± 69.6 m 比 -0.5 ± 87.3 m；p = 0.04）。然而，运动训练后，两组恒定负荷运动试验持续时间的改善程度没有显著差异。
考虑到对日常活动（例如行走）的影响，使用高 FO 和高流量通过 HFNC 进行运动训练可能是接受 LTOT 的 CRF 患者的一种更优的运动训练方式。临床试验注册-http://www.。
CLINICALTRIALS.gov。独特标识符：NCT02804243。
