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转录组分析显示 ITGB1 高表达可作为预测胰腺癌不良预后的指标。

Transcriptomic analysis reveals high ITGB1 expression as a predictor for poor prognosis of pancreatic cancer.

机构信息

Division of Hepato-Biliary-Pancreatic Surgery, Chiba Cancer Center, Chiba, Japan.

Department of Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

出版信息

PLoS One. 2022 Jun 1;17(6):e0268630. doi: 10.1371/journal.pone.0268630. eCollection 2022.

DOI:10.1371/journal.pone.0268630
PMID:35648752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9159604/
Abstract

Transcriptomic analysis of cancer samples helps identify the mechanism and molecular markers of cancer. However, transcriptomic analyses of pancreatic cancer from the Japanese population are lacking. Hence, in this study, we performed RNA sequencing of fresh and frozen pancreatic cancer tissues from 12 Japanese patients to identify genes critical for the clinical pathology of pancreatic cancer among the Japanese population. Additionally, we performed immunostaining of 107 pancreatic cancer samples to verify the results of RNA sequencing. Bioinformatics analysis of RNA sequencing data identified ITGB1 (Integrin beta 1) as an important gene for pancreatic cancer metastasis, progression, and prognosis. ITGB1 expression was verified using immunostaining. The results of RNA sequencing and immunostaining showed a significant correlation (r = 0.552, p = 0.118) in ITGB1 expression. Moreover, the ITGB1 high-expression group was associated with a significantly worse prognosis (p = 0.035) and recurrence rate (p = 0.028). We believe that ITGB1 may be used as a drug target for pancreatic cancer in the future.

摘要

对癌症样本进行转录组分析有助于确定癌症的机制和分子标志物。然而，缺乏对日本人群胰腺癌的转录组分析。因此，在这项研究中，我们对 12 名日本患者的新鲜和冷冻胰腺癌组织进行了 RNA 测序，以鉴定日本人群中与胰腺癌临床病理相关的关键基因。此外，我们对 107 个胰腺癌样本进行了免疫染色，以验证 RNA 测序的结果。RNA 测序数据的生物信息学分析将 ITGB1（整合素β 1）鉴定为胰腺癌转移、进展和预后的重要基因。使用免疫染色验证了 ITGB1 的表达。RNA 测序和免疫染色的结果显示 ITGB1 表达具有显著相关性（r = 0.552，p = 0.118）。此外，ITGB1 高表达组与预后明显较差（p = 0.035）和复发率较高（p = 0.028）相关。我们相信，ITGB1 可能成为未来胰腺癌的药物靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/a5a99887e91d/pone.0268630.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/a175a4a127cd/pone.0268630.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/108f510e2d7c/pone.0268630.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/de7ebddea63b/pone.0268630.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/fac70a358619/pone.0268630.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/a5a99887e91d/pone.0268630.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/a175a4a127cd/pone.0268630.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/108f510e2d7c/pone.0268630.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/de7ebddea63b/pone.0268630.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/fac70a358619/pone.0268630.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c28/9159604/a5a99887e91d/pone.0268630.g005.jpg

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本文引用的文献

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