聚（N-乙烯基己内酰胺）-聚乙二醇-聚（N-乙烯基己内酰胺）热敏性可生物降解水凝胶的设计与表征

Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel.

作者信息

Vidyasagar Ajay, Ku Sook Hee, Kim Minchul, Kim Mihee, Lee Han Seung, Pearce Timothy R, McCormick Alon V, Bates Frank S, Kokkoli Efrosini

机构信息

Department of Chemical Engineering and Materials Science and ∥Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Department of Chemical Engineering and Materials Science and Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.

出版信息

ACS Macro Lett. 2017 Oct 17;6(10):1134-1139. doi: 10.1021/acsmacrolett.7b00523. Epub 2017 Sep 28.

DOI:10.1021/acsmacrolett.7b00523

PMID:35650931

Abstract

A set of poly(δ-valerolactone--d,l-lactide)--poly(ethylene glycol)--poly(δ-valerolactone--d,l-lactide) (PVLA-PEG-PVLA) triblock copolymers was synthesized and the solution properties were characterized using rheology, cryo-TEM, cryo-SEM, SANS, and degradation studies. This polymer self-assembles into a low viscosity fluid with flowerlike spherical micelles in water at room temperature and transforms into a wormlike morphology upon heating, accompanied by gelation. At even higher temperatures syneresis is observed. At physiological temperature (37 °C) the hydrogel's average pore size is around 600 nm. The PVLA-PEG-PVLA gel degrades in about 45 days in cell media, making this unique hydrogel a promising candidate for biomedical applications.

摘要

合成了一组聚（δ-戊内酯 - d，l-丙交酯）-聚（乙二醇）-聚（δ-戊内酯 - d，l-丙交酯）（PVLA-PEG-PVLA）三嵌段共聚物，并使用流变学、低温透射电子显微镜、低温扫描电子显微镜、小角中子散射和降解研究对其溶液性质进行了表征。这种聚合物在室温下在水中自组装成具有花状球形胶束的低粘度流体，加热时转变为蠕虫状形态，并伴有凝胶化。在更高的温度下会观察到脱水收缩。在生理温度（37°C）下，水凝胶的平均孔径约为600nm。PVLA-PEG-PVLA凝胶在细胞培养基中约45天降解，使这种独特的水凝胶成为生物医学应用的有前途的候选者。