Department of Biology, University of Patras - Patras Campus Rion: Panepistemio Patron, Patras, Greece.
Department of Dietetics and Nutrition, Harokopio University, Athens, Greece.
Nutr Neurosci. 2023 Jul;26(7):652-666. doi: 10.1080/1028415X.2022.2080792. Epub 2022 Jun 3.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of nigral dopaminergic neurons, leading to reduced motor control. A contributing factor for the nigrostriatal degeneration is known to be oxidative stress, while antioxidant/anti-inflammatory properties of natural polyphenols have been suggested to show beneficial effects. The present study questioned the potential neuroprotective effects of supplementary diet with , using a rat rotenone PD model.
The alterations in motor activity, brain Corinthian currant polar phenols' accumulation, expression patterns of tyrosine hydroxylase (TH), dopamine transporter (DAT) and brain-derived neurotrophic factor (BDNF) in the nigrostriatal dopaminergic system were determined in rotenone-treated, currant-diet rats and matching controls.
Rotenone treatment resulted in motor deficits and TH expression decreases in the nigrostriatal pathway, exhibiting PD-like behavioural motor and neurochemical phenotypes. Interestingly, 38 days Corinthian currant consumption resulted in differential accumulation of polar phenols in mesencephalon and striatum and had a significant effect on attenuating motor deficits and dopaminergic cell loss in substantia nigra pars compacta. In addition, it induced up-regulation of BDNF expression in the nigrostriatal dopaminergic system.
Taken all together, evidence is provided for the potential neuroprotective influences of Corinthian currant consumption, involving the neurotrophic factor BDNF, in rescuing aspects of PD-like phenotype.
帕金森病（PD）是一种进行性神经退行性疾病，其特征是黑质多巴胺能神经元丧失，导致运动控制能力下降。已知氧化应激是黑质纹状体变性的一个促成因素，而天然多酚的抗氧化/抗炎特性被认为具有有益的作用。本研究使用鱼藤酮 PD 大鼠模型，探讨补充饮食对的潜在神经保护作用。
在鱼藤酮处理的红醋栗饮食大鼠和匹配的对照组中，测定运动活动、大脑中姜黄素极性酚类物质的积累、酪氨酸羟化酶（TH）、多巴胺转运蛋白（DAT）和脑源性神经营养因子（BDNF）在黑质纹状体多巴胺能系统中的表达模式的变化。
鱼藤酮处理导致黑质纹状体通路出现运动缺陷和 TH 表达减少，表现出类似 PD 的行为运动和神经化学表型。有趣的是，38 天红醋栗的摄入导致中脑和纹状体中极性酚类物质的差异积累，并对减轻黑质致密部的运动缺陷和多巴胺能细胞丢失有显著影响。此外，它诱导了黑质纹状体多巴胺能系统中 BDNF 表达的上调。
综上所述，红醋栗的摄入具有潜在的神经保护作用，涉及神经营养因子 BDNF，可挽救 PD 样表型的某些方面。
