Department of Ophthalmology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Optom Vis Sci. 2022 Jun 1;99(6):540-543. doi: 10.1097/OPX.0000000000001887. Epub 2022 Feb 25.
We demonstrate the clinical correlation between the vitamin A level with chalazion in East Chinese children. Vitamin A deficiency is likely to be a potential cause of childhood chalazion.
Chalazion is the most common lid inflammatory lesion of the eyelid, which can be caused by retention of tarsal gland secretions. Studies have revealed that vitamin deficiency is an essential risk factor for children with chalazion. In this study, we measured the serum levels of vitamin A and 25-hydroxyvitamin D (25(OH)D), in patients with chalazion.
The study included 180 subjects (90 patients with chalazion and 90 control healthy subjects) with an average age of 4.13 ± 2.01 years, and 47.8% of whom were female. Serums came from blood samples collected and used to measure the levels of vitamin A and 25(OH)D.
Both groups had statistically similar baseline characteristics, including age and body mass index. The average serum vitamin A levels in patients with chalazion (0.54 ± 0.15 μmol/L) were significantly lower than in their control counterparts (0.60 ± 0.15 μmol/L; P = .01). There was no significant difference in the serum 25(OH)D levels between the patients (70.15 ± 19.73 nmol/L) and control subjects (71.64 ± 24.46 nmol/L). The percentage of vitamin A deficiency in chalazion group (52.2%) was much higher than the control counterparts (28.6%; P = .001). The percentage of 25(OH)D deficiency showed no significant difference between patients with chalazion and control subjects (58.9 vs. 56.7%).
Low serum vitamin A was significantly associated with chalazion in children. The serum 25(OH)D level exhibited no correlation with chalazion.
我们证明了维生素 A 水平与华东地区儿童霰粒肿之间的临床相关性。维生素 A 缺乏可能是儿童霰粒肿的潜在原因。
霰粒肿是最常见的眼睑炎性病变，可由睑板腺分泌物潴留引起。研究表明，维生素缺乏是儿童霰粒肿的一个重要危险因素。在这项研究中，我们测量了患有霰粒肿的患者的血清维生素 A 和 25-羟维生素 D（25(OH)D）水平。
该研究纳入了 180 名受试者（90 名霰粒肿患者和 90 名健康对照者），平均年龄为 4.13±2.01 岁，其中 47.8%为女性。血清取自采集的血液样本，用于测量维生素 A 和 25(OH)D 水平。
两组在年龄和体重指数等基线特征方面具有统计学上的相似性。霰粒肿患者的平均血清维生素 A 水平（0.54±0.15 μmol/L）明显低于对照组（0.60±0.15 μmol/L；P=0.01）。患者（70.15±19.73 nmol/L）和对照组（71.64±24.46 nmol/L）的血清 25(OH)D 水平无显著差异。霰粒肿组的维生素 A 缺乏率（52.2%）明显高于对照组（28.6%；P=0.001）。患者与对照组的 25(OH)D 缺乏率无显著差异（58.9%对 56.7%）。
血清维生素 A 水平降低与儿童霰粒肿显著相关。血清 25(OH)D 水平与霰粒肿无相关性。
