蓝斑核活动与淀粉样蛋白相关认知衰退之间的新联系。
A novel link between locus coeruleus activity and amyloid-related cognitive decline.
机构信息
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
出版信息
Trends Neurosci. 2022 Sep;45(9):651-653. doi: 10.1016/j.tins.2022.05.006. Epub 2022 May 31.
Abstract
Recent work from Prokopiou, Engels-Domínguez et al. assessed locus coeruleus (LC) activity and its functional connectivity (FC) to forebrain regions during a novelty task in cognitively unimpaired adult individuals with varying degrees of amyloid deposition. Novelty increased LC activity and LC FC, but lower responses on these measures were associated with steeper cognitive decline in amyloid-positive individuals.
摘要
最近，Prokopiou、Engels-Domínguez 等人评估了认知正常的成年个体在新颖性任务期间蓝斑（LC）的活动及其与前脑区域的功能连接（FC），这些个体的淀粉样蛋白沉积程度不同。新颖性增加了 LC 的活动和 LC 的 FC，但这些指标上的反应较低与淀粉样蛋白阳性个体认知衰退的加剧有关。
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