采用硅光电倍增管技术正电子发射断层扫描/计算机断层扫描的内部幅度门控呼吸方法的体模研究。

Phantom study of an in-house amplitude-gating respiratory method with silicon photomultiplier technology positron emission tomography/computed tomography.

机构信息

Nuclear Medicine Department, Amiens University Medical Center, Amiens, France; Department of Nuclear Medicine, Amiens University Hospital, Amiens, France.

出版信息

Comput Methods Programs Biomed. 2022 Jun;221:106907. doi: 10.1016/j.cmpb.2022.106907. Epub 2022 May 27.

DOI:10.1016/j.cmpb.2022.106907

PMID:35660941

Abstract

PURPOSE

The objective of this phantom study was to determine whether breathing-synchronized, silicon photomultiplier (SiPM)-based PET/CT has a suitable acquisition time for routine clinical use.

METHODS

Acquisitions were performed in list mode on a 4-ring SiPM-based PET/CT system. The experimental setup consisted of an external respiratory tracking device placed on a commercial dynamic thorax phantom containing a sphere filled with [F-18]-fluorodeoxyglucose. Three-dimensional sinusoidal motion was imposed on the sphere. Data were processed using frequency binning and amplitude binning (the "DMI" and "OFFLINE" methods, respectively). PET sinograms were reconstructed with a Bayesian penalized likelihood algorithm.

RESULTS

Respiratory gating from a 150‑sec acquisition was successful. The DMI and OFFLINE methods gave similar activity profiles but both were slightly shifted in space; the latter profile was closest to the reference acquisition.

CONCLUSION

With SiPM PET/CT systems, the amplitude-based processing of breathing-synchronized data is likely to be feasible in routine clinical practice.

摘要

目的

本研究旨在探讨基于硅光电倍增管（SiPM）的呼吸门控 PET/CT 是否具有适用于常规临床应用的合适采集时间。

方法

采用基于 4 环 SiPM 的 PET/CT 系统以列表模式进行采集。实验设置包括放置在商业动态胸部体模上的外部呼吸跟踪装置，该体模内含有一个充满 [F-18]-氟脱氧葡萄糖的球体。球体被施加三维正弦运动。使用频率分箱和幅度分箱（分别为“DMI”和“OFFLINE”方法）对数据进行处理。使用贝叶斯惩罚似然算法重建 PET 正弦图。