疟疾青蒿素耐药性：外泌体外排假说。

Malaria artemisinin resistance: an extracellular vesicles export hypothesis.

机构信息

West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.

出版信息

Trends Parasitol. 2022 Aug;38(8):614-617. doi: 10.1016/j.pt.2022.05.004. Epub 2022 Jun 2.

DOI:10.1016/j.pt.2022.05.004

PMID:35661626

Abstract

Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) - a drug used for managing malaria - threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.

摘要

恶性疟原虫引起疟疾，其对青蒿素（ART）的耐药性——一种用于治疗疟疾的药物——可能会干扰疟疾的有效控制。ART 耐药性（ARTr）是由对氧化应激的耐受性增加和血红蛋白向食物泡转运减少驱动的。我们讨论了细胞外囊泡（EVs）如何在产生 ARTr 方面发挥作用。