Division of Maternal Fetal Medicine and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
Am J Perinatol. 2024 May;41(7):884-890. doi: 10.1055/s-0042-1748526. Epub 2022 Jun 3.
To evaluate the hypothesis that patients with opioid use disorder (OUD), who receive prenatal care in a multidisciplinary, prenatal OUD clinic, have comparable postpartum breastfeeding rates, prenatal and postpartum visit compliance, and postpartum contraceptive use when compared with matched controls without a diagnosis of OUD.
This was a retrospective, matched, cohort study that included all patients who received prenatal care in a multidisciplinary, prenatal OUD clinic-Clinic for Acceptance Recovery and Empowerment (CARE)-between September 2018 and August 2020. These patients were maintained on opioid agonist therapy (OAT) throughout their pregnancy. CARE patients were matched to controls without OUD in a 1:4 ratio for mode of delivery, race, gestational age ± 1 week, and delivery date ± 6 months. The primary outcome was rate of exclusive breastfeeding at maternal discharge. Secondary outcomes included adherence with prenatal care (≥4 prenatal visits), adherence with postpartum care (≥1 postpartum visit), postpartum contraception plan prior to delivery, and type of postpartum contraceptive use. Conditional multivariate logistic regression was used to account for possible confounders in adjusted calculations.
A total of 210 patients were included (42 CARE and 168 matched controls). Despite having lower rates of adequate prenatal care, 40 CARE patients (95%) were exclusively breastfeeding at discharge resulting in CARE patients being significantly more likely to be breastfeeding at discharge (adjusted relative risk (aRR): 1.28, 95% confidence interval [CI]: 1.05-1.55). CARE patients and controls demonstrated no difference in postpartum visit compliance (86 vs. 81%, aRR: 1.03, 95% CI: 0.76-1.40) or effective, long-term contraception use (48 vs. 48%; aRR: 0.81, 95% CI: 0.36-1.84).
In the setting of multidisciplinary OUD prenatal care during pregnancy, patients with OUD were more likely to be breastfeeding at the time of discharge than matched controls, with no difference in postpartum visit compliance or effective, long-term contraception.
· Women with OUD are more likely to breastfeed when engaged in a multidisciplinary prenatal clinic.. · Women with OUD had no difference in LARC use when engaged in a multidisciplinary prenatal clinic.. · Women with OUD had no difference in postpartum visit rate in a multidisciplinary prenatal clinic..
评估以下假设,即在多学科产前阿片类药物使用障碍(OUD)诊所接受产前护理的 OUD 患者,与未诊断为 OUD 的匹配对照组相比,具有可比的产后母乳喂养率、产前和产后就诊依从性以及产后避孕措施使用率。
这是一项回顾性、匹配队列研究,纳入了 2018 年 9 月至 2020 年 8 月期间在多学科产前 OUD 诊所-Clinic for Acceptance Recovery and Empowerment(CARE)接受产前护理的所有患者。这些患者在整个孕期均接受阿片类激动剂治疗(OAT)。按照分娩方式、种族、孕龄±1 周和分娩日期±6 个月,以 1:4 的比例将 CARE 患者与无 OUD 的对照组进行匹配。主要结局是产妇出院时的纯母乳喂养率。次要结局包括产前护理(≥4 次产前就诊)、产后护理(≥1 次产后就诊)、分娩前的产后避孕计划以及产后避孕措施的使用类型。条件多变量逻辑回归用于调整计算中可能存在的混杂因素。
共纳入 210 名患者(42 名 CARE 和 168 名匹配对照组)。尽管 CARE 患者接受充分产前护理的比例较低,但 40 名 CARE 患者(95%)在出院时进行纯母乳喂养,这使得 CARE 患者出院时更有可能进行母乳喂养(调整后的相对风险(aRR):1.28,95%置信区间[CI]:1.05-1.55)。CARE 患者和对照组在产后就诊依从性(86%与 81%,aRR:1.03,95%CI:0.76-1.40)或有效、长期避孕措施的使用(48%与 48%,aRR:0.81,95%CI:0.36-1.84)方面没有差异。
在孕期多学科 OUD 产前护理的背景下,OUD 患者在出院时母乳喂养的可能性高于匹配对照组,且产后就诊依从性或有效、长期避孕措施方面无差异。
· 接受多学科产前诊所治疗的 OUD 女性更有可能进行母乳喂养。· 接受多学科产前诊所治疗的 OUD 女性在使用长效可逆避孕措施(LARC)方面没有差异。· 接受多学科产前诊所治疗的 OUD 女性在产后就诊率方面没有差异。