Abdul-Hasan Mazin Thamir, Omara Ali M, Al-Koofee Dhafer A F
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Kufa, Najaf, Iraq.
Department of Clinical Biochemistry, Faculty of Medicine, University of Al-Ameed, Karbala, Iraq.
J Diabetes Metab Disord. 2022 Apr 21;21(1):727-733. doi: 10.1007/s40200-022-01041-z. eCollection 2022 Jun.
Coronary artery disease (CAD) is a major cause of death worldwide. There is relatively little data available on the genetic susceptibility to CAD in the Iraqi population. We have therefore investigated the association between angiotensin II type 1 receptor gene polymorphism A1166C and the presence of CAD in a sample of the Iraqi population.
This case-control study enrolled 150 CAD patients, with CAD confirmed by coronary angiography, and 200 controls. The AT1R polymorphism A1166C was analyzed by the allele-specific polymerase chain reaction (AS-PCR) technique. Serum analyses, such as lipid concentrations, were measured and analyzed.
The C allele and CC genotype frequencies were significantly higher in patients with CAD compared to the controls. Logistic regression analysis showed that the codominant, dominant, and recessive models were associated with risk of CAD of (OR = 1.32, 95% CI: 1.2-1.4, P = 0.000; OR = 1.25, 95% CI: 1.1-1.3, P = 0.000, OR = 1.27, 95% CI: 1.1-1.3, P = 0.000, OR = 1.18, 95% CI: 1.0-1.4), respectively. In the patient group, the presence of the mutant C allele was significantly associated with higher levels of CAD risk factors such as total cholesterol (TC) and low-density lipoprotein (LDL).
The study indicated that the A1166C polymorphism may be associated with the presence of CAD in the Iraqi population. The AT1R polymorphism may therefore be a useful marker of susceptibility to CAD.
冠状动脉疾病（CAD）是全球主要的死亡原因。关于伊拉克人群中CAD遗传易感性的数据相对较少。因此，我们调查了血管紧张素II 1型受体基因多态性A1166C与伊拉克人群样本中CAD存在情况之间的关联。
本病例对照研究纳入了150例经冠状动脉造影确诊为CAD的患者和200例对照。采用等位基因特异性聚合酶链反应（AS-PCR）技术分析AT1R多态性A1166C。测量并分析血清指标，如血脂浓度。
与对照组相比，CAD患者中C等位基因和CC基因型频率显著更高。逻辑回归分析显示，共显性、显性和隐性模型与CAD风险分别相关（OR = 1.32，95% CI：1.2 - 1.4，P = 0.000；OR = 1.25，95% CI：1.1 - 1.3，P = 0.000，OR = 1.27，95% CI：1.1 - 1.3，P = 0.000，OR = 1.18，95% CI：1.０ - 1.4）。在患者组中，突变C等位基因的存在与总胆固醇（TC）和低密度脂蛋白（LDL）等更高水平的CAD危险因素显著相关。
该研究表明，A1166C多态性可能与伊拉克人群中CAD的存在有关。因此，AT1R多态性可能是CAD易感性的一个有用标志物。
