Patil Shivaraj, Rojulpote Chaitanya, Amanullah Aman
Department of Cardiology, Einstein Medical Center, Philadelphia, PA, United States.
Department of Medicine, The Wright Center for Graduate Medical Education, Scranton, PA, United States.
Front Cardiovasc Med. 2022 May 23;9:882330. doi: 10.3389/fcvm.2022.882330. eCollection 2022.
Cardiovascular disease, in particular ischemic heart disease is a major cause of morbidity and mortality worldwide. Primary aldosteronism is the leading cause of secondary hypertension, yet commonly under diagnosed, and represents a major preventable risk factor. In contrast to historical teaching, recent studies have shown that excess aldosterone production is associated with increased burden of ischemic heart disease disproportionate to the effects caused by hypertension alone. Aldosterone through its genomic and non-genomic actions exerts various detrimental cardiovascular changes contributing to this elevated risk. Recognition of primary hyperaldosteronism and understanding the distinctive pathophysiology of ischemic heart disease in primary aldosteronism is crucial to develop strategies to improve outcomes.
心血管疾病，尤其是缺血性心脏病，是全球发病和死亡的主要原因。原发性醛固酮增多症是继发性高血压的主要病因，但常常未被诊断出来，是一个主要的可预防风险因素。与以往的认识不同，最近的研究表明，醛固酮分泌过多与缺血性心脏病负担增加有关，这种增加与单纯高血压所造成的影响不成比例。醛固酮通过其基因组和非基因组作用，引发各种有害的心血管变化，导致风险升高。识别原发性醛固酮增多症并了解原发性醛固酮增多症中缺血性心脏病独特的病理生理学，对于制定改善治疗效果的策略至关重要。
