耐多药微生物所致的脑脊液引流相关脑室炎
Cerebrospinal fluid drainage-related ventriculitis due to multidrug-resistant microorganisms.
作者信息
Solo-Peleteiro Adriana, Diéguez Patricia, Pérez-Rodríguez María Teresa, Galárraga Raul A, Pérez-Landeiro Antonio, Álvarez-Fernández Maximiliano
机构信息
Infectious Diseases Unit, Department of Internal Medicine, Complexo Hospitalario Universitario de Vigo, Spain.
Infectious Diseases Unit, Department of Internal Medicine, Complexo Hospitalario Universitario de Vigo, Spain; Instituto de Investigación Biomédica Galicia Sur, Spain.
出版信息
Enferm Infecc Microbiol Clin (Engl Ed). 2022 Jun-Jul;40(6):322-325. doi: 10.1016/j.eimce.2020.12.005.
INTRODUCTION
The aim of the study was to analyze the clinical and microbiological characteristics of adult patients with cerebrospinal fluid (CSF) drainage-related ventriculitis.
METHODS
Retrospective study from January 2010 to June 2019 performed in the Complexo Hospitalario Universitario de Vigo (Spain). Cases of CSF drainage-related ventriculitis in patients ≥18-year-old were gathered. Clinical characteristics of patients, type of drainage devices, management and microbiological isolates were analyzed.
RESULTS
Ninety-one episodes of CSF drainage-related ventriculitis were identified. The most frequent organisms isolated were Gram-positive cocci (65%), mainly Staphylococcus epidermidis (48%). Multidrug-resistant microorganisms were detected in 21 episodes (23%). In multivariate analysis, the independent factors related with multidrug-resistant ventriculitis were the length of hospital stay >14 days (HR 6.7; 95%CI 1.75-25.86, p=0.006) and previous antimicrobial therapy (HR 5.58; 95%CI 1.44-21.65, p=0.013).
CONCLUSIONS
Our study shows a large number of drainage-related ventriculitis episodes caused by multidrug-resistant organisms and reinforce the importance of a judicious use of antibiotics.
引言
本研究旨在分析脑脊液（CSF）引流相关脑室炎成年患者的临床和微生物学特征。
方法
对西班牙维戈大学综合医院2010年1月至2019年6月进行的回顾性研究。收集≥18岁患者脑脊液引流相关脑室炎的病例。分析患者的临床特征、引流装置类型、治疗及微生物分离株情况。
结果
共确定91例脑脊液引流相关脑室炎发作。分离出的最常见病原体为革兰氏阳性球菌（65%），主要是表皮葡萄球菌（48%）。21例发作（23%）检测到多重耐药微生物。多因素分析显示，与多重耐药脑室炎相关的独立因素为住院时间>14天（HR 6.7；95%CI 1.75 - 25.86，p = 0.006）和先前的抗菌治疗（HR 5.58；95%CI 1.44 - 21.65，p = 0.013）。
结论
我们的研究显示大量引流相关脑室炎发作由多重耐药病原体引起，并强调了合理使用抗生素的重要性。
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