根据间质性肺疾病的存在情况，特发性炎性肌病患者肌肉中炎症标志物的表达
Expression of Inflammatory Markers in the Muscles of Patients with Idiopathic Inflammatory Myopathy According to the Presence of Interstitial Lung Disease.
作者信息
Lee Jung Sun, Ghang Byeongzu, Choi Wonho, Hong Seokchan, Kim Yong-Gil, Lee Chang-Keun, Nam Soo Jeong, Yoo Bin
机构信息
Division of Rheumatology, Department of Internal Medicine, Seoul Veterans Hospital, Seoul 05368, Korea.
Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
出版信息
J Clin Med. 2022 May 27;11(11):3021. doi: 10.3390/jcm11113021.
BACKGROUND
Several studies have identified factors associated with the development of interstitial lung disease (ILD) in patients with idiopathic inflammatory myopathies (IIMs). However, few have assessed the association between ILD and muscle biopsy findings, including inflammatory marker expressions analyzed using immunohistochemistry (IHC).
METHODS
Muscle biopsies from patients who were newly diagnosed with IIMs between 2000 and 2017 were reviewed. ILD was diagnosed based on chest computed tomography findings at the time of diagnosis of IIMs. IHC staining was performed for CD3, CD4, CD8, CD20, CD68, CD163, MX1, MHC class I, and HLA-DR. The factors associated with the presence of ILD were evaluated by logistic regression analysis.
RESULTS
Of the 129 patients with IIM, 49 (38%) had ILD. In the muscle biopsy findings, CD4 expression, MX1 expression on immune cells, and expression of MHC class I and HLA-DR on myofibers were more common in patients with ILD than those without. In the logistic regression analysis, the HLA-DR expression on myofibers was significantly associated with the risk of ILD (OR, 2.39; 95% CI, 1.24-4.90, = 0.012) after adjusting for pathologic findings, clinical features, and autoantibodies.
CONCLUSION
The expression of HLA-DR on myofibers was associated with the presence of ILD in patients with IIM.
背景
多项研究已确定了与特发性炎性肌病（IIM）患者间质性肺病（ILD）发生相关的因素。然而，很少有研究评估ILD与肌肉活检结果之间的关联，包括使用免疫组织化学（IHC）分析的炎症标志物表达。
方法
回顾了2000年至2017年间新诊断为IIM的患者的肌肉活检情况。根据IIM诊断时的胸部计算机断层扫描结果诊断ILD。对CD3、CD4、CD8、CD20、CD68、CD163、MX1、MHC I类和HLA-DR进行IHC染色。通过逻辑回归分析评估与ILD存在相关的因素。
结果
在129例IIM患者中，49例（38%）患有ILD。在肌肉活检结果中，与无ILD的患者相比，有ILD的患者中CD4表达、免疫细胞上的MX1表达以及肌纤维上的MHC I类和HLA-DR表达更为常见。在逻辑回归分析中，在调整病理结果、临床特征和自身抗体后，肌纤维上的HLA-DR表达与ILD风险显著相关（OR，2.39；95%CI，1.24 - 4.90，P = 0.012）。
结论
IIM患者中肌纤维上HLA-DR的表达与ILD的存在相关。
Zotero 插件