Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Surg Oncol. 2022 Sep;126(4):640-648. doi: 10.1002/jso.26983. Epub 2022 Jun 11.
The aim of the present study was to investigate the differences in quality of life (QOL) following complete or partial thyroidectomy and with regard to thyroid hormone replacement (LT4) therapy.
Patients who underwent thyroidectomy were asked to complete the validated thyroid-specific ThyPRO QOL questionnaire at least 6 months following surgery.
Tertiary medical center.
Thyroid specific QOL questionnaire analysis.
A total of 190 patients completed the ThyPRO questionnaire. Of them 89 patients had complete thyroidectomy and 101 patients had unilateral thyroid lobectomy. The total thyroidectomy group had significantly worse overall QOL self-assessment score than the lobectomy patients (p < 0.0001). Patients receiving LT4 therapy regardless of the extent of surgery, reported worse QOL compared to patients not receiving LT4.
Quality of life following thyroid surgery is significantly related to hypothyroidism and the requirement for LT4 therapy, rather to the extent of surgery. The best QOL was reported in patients treated with lobectomy who did not require LT4 therapy.
本研究旨在探讨全甲状腺切除术与甲状腺部分切除术患者术后生活质量（QOL）的差异，并观察甲状腺激素替代治疗（LT4）的影响。
甲状腺切除术患者术后至少 6 个月，使用经过验证的甲状腺特异性 ThyPRO QOL 问卷进行调查。
三级医疗中心。
对甲状腺特异性 QOL 问卷进行分析。
共有 190 例患者完成了 ThyPRO 问卷。其中 89 例患者行全甲状腺切除术，101 例行单侧甲状腺叶切除术。全甲状腺切除术组的总体 QOL 自我评估评分明显低于叶切除术组（p<0.0001）。无论手术范围如何，接受 LT4 治疗的患者报告的 QOL 均差于未接受 LT4 治疗的患者。
甲状腺手术后的生活质量与甲状腺功能减退和 LT4 治疗的需求密切相关，而与手术范围无关。在未接受 LT4 治疗的患者中，行甲状腺叶切除术的患者报告的 QOL 最佳。
Zotero 插件
