Bozkurt Erdinc, Cetin Turkhun, Rencuzogullari Ibrahim
Department of Ophthalmology, Kafkas University, Kars, Turkey.
Department of Radiology, Kafkas University, Kars, Turkey.
Beyoglu Eye J. 2022 May 27;7(2):126-133. doi: 10.14744/bej.2022.44265. eCollection 2022.
Our aim in this study was to evaluate the systemic endothelial dysfunction status and carotid intima-media thickness (CIMT) in patients with retinal vein occlusion (RVO).
Seventy-six patients who presented to the clinic with the diagnosis of RVO and 76 age- and gender-matched healthy individuals without a RVO history were included in the study. The patients' best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measures, and diabetes, hypertension, hyperlipidemia, carotid artery disease, body mass index, and smoking histories were recorded. The endothelial function levels of the patients, pulse wave velocity (PWV), flow-mediated dilation (FMD), and CIMT were measured. Endothelial dysfunction was detected by applying the FMD technique to the brachial artery. CIMT was evaluated by B-mode ultrasonography. Serum hematological parameters were evaluated.
BCVA (logMAR) was 1.39±1.30 in patients with RVO and 0.028±1.22 in the control group (p<0.001). CMT was 588.76±104.02 µm in patients with RVO and 265.20±45.11 µm in the control group (p=0.001). Hypertension, diabetes, and hyperlipidemia were found to be significantly higher in patients with RVO (p-value 0.001, 0.002, and 0.001, respectively). There was a significant difference between the groups in terms of FMD, PWV, and CIMT (all of them, p<0.001).
The deterioration of FMD and PWV, which are indicators of endothelial dysfunction in patients with RVO, suggests that systemic endothelial dysfunction may play a role in the pathogenesis of RVO. Comprehensive studies with more patient participation are needed.
本研究旨在评估视网膜静脉阻塞（RVO）患者的全身内皮功能障碍状态及颈动脉内膜中层厚度（CIMT）。
本研究纳入了76例临床诊断为RVO的患者以及76例年龄和性别匹配、无RVO病史的健康个体。测量患者的最佳矫正视力（BCVA）和中心黄斑厚度（CMT），并记录糖尿病、高血压、高脂血症、颈动脉疾病、体重指数和吸烟史。测量患者的内皮功能水平、脉搏波速度（PWV）、血流介导的血管舒张功能（FMD）和CIMT。通过将FMD技术应用于肱动脉来检测内皮功能障碍。通过B型超声评估CIMT。评估血清血液学参数。
RVO患者的BCVA（logMAR）为1.39±1.30，对照组为0.028±1.22（p<0.001）。RVO患者的CMT为588.76±104.02 µm，对照组为265.20±45.11 µm（p=0.001）。发现RVO患者的高血压、糖尿病和高脂血症显著更高（p值分别为0.001、0.002和0.001）。两组在FMD、PWV和CIMT方面存在显著差异（所有p值均<0.001）。
RVO患者内皮功能障碍指标FMD和PWV的恶化表明全身内皮功能障碍可能在RVO的发病机制中起作用。需要更多患者参与的综合研究。
