小鼠唾液雄激素结合蛋白（ABP）α和γ亚基的基因位于7号染色体上。
The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7.
作者信息
Dlouhy S R, Taylor B A, Karn R C
出版信息
Genetics. 1987 Mar;115(3):535-43. doi: 10.1093/genetics/115.3.535.
Abstract
We demonstrate that the previously described gene Androgen binding protein (Abp; Dlouhy and Karn, 1984) codes for the Alpha subunit of ABP and rename the locus Androgen binding protein alpha (Abpa). A study of recombinant inbred strains demonstrates that Abpa is located on chromosome 7 near Glucose phosphate isomerase-1 (Gpi-1). Biochemical and genetic evidence indicates the existence of another ABP subunit, Gamma, and its locus, Androgen binding protein gamma (Abpg), that is closely linked to Abpa. Although no polymorphism has yet been found for the previously described Beta subunit of ABP (Dlouhy and Karn, 1983; 1984), we suggest that it represents a third locus. Androgen binding protein beta (Abpb). ABP subunits appear to dimerize randomly and a model is presented demonstrating the origin of six ABP dimers in the salivas of AbpaaAbpga/AbpabAbpgb heterozygous mice. The results of cell-free translation studies in which the pre-ABP subunits are identified specifically by immunoprecipitation with anti-ABP antibody supports the idea that independent mRNAs code for the Alpha, Beta and Gamma subunits.
摘要
我们证明，先前描述的雄激素结合蛋白基因（Abp；Dlouhy和Karn，1984年）编码ABP的α亚基，并将该基因座重新命名为雄激素结合蛋白α（Abpa）。对重组近交系的研究表明，Abpa位于7号染色体上靠近磷酸葡萄糖异构酶-1（Gpi-1）的位置。生化和遗传学证据表明存在另一个ABP亚基γ及其基因座雄激素结合蛋白γ（Abpg），它与Abpa紧密连锁。尽管尚未发现先前描述的ABPβ亚基（Dlouhy和Karn，1983年；1984年）存在多态性，但我们认为它代表第三个基因座，即雄激素结合蛋白β（Abpb）。ABP亚基似乎随机二聚化，并提出了一个模型，展示了AbpaaAbpga/AbpabAbpgb杂合小鼠唾液中六种ABP二聚体的起源。无细胞翻译研究的结果通过用抗ABP抗体免疫沉淀特异性鉴定前ABP亚基，支持了独立的mRNA编码α、β和γ亚基的观点。
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