Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, 7 Universities Zone, New Minia 61111, Egypt.
Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, 62513 Beni-Suef, Egypt.
Food Funct. 2022 Jul 4;13(13):6859-6874. doi: 10.1039/d2fo00834c.
Ischemia is a deadly disease featured by restricted perfusion to different organs in the body. An increase in the accumulation of reactive oxygen species and cell debris is the driving force for inducing many oxidative, inflammatory and apoptotic signaling pathways. However, the number of therapeutics existing for ischemic stroke patients is limited and there is insufficient data on their efficiency, which warrants the search for novel therapeutic candidates from natural sources. Herein, a comprehensive survey was done on the reported functional food bioactives ( 152 compounds) to manage or protect against health consequences of myocardial and cerebral ischemia. Furthermore, we reviewed the reported mechanistic studies for their anti-ischemic potential. Subsequently, network pharmacology- and -based studies were conducted using the reported myocardial and cerebral ischemia-relevant molecular targets to study their complex interactions and highlight key targets in disease pathogenesis. Subsequently, the most prominent 20 compounds in the literature were used in a comprehensive -based analysis (inverse docking, Δ calculation and molecular dynamics simulation) to determine other potential targets for these compounds and their probable interactions with different signaling pathways relevant to this disease. Many functional food bioactives, belonging to different chemical classes, , flavonoids, saponins, phenolics, alkaloids, iridoids and carotenoids, were proven to exhibit multifactorial effects in targeting the complex pathophysiology of ischemic conditions. These merits make them valuable therapeutic agents that can outperform the conventional drugs, and hence they can be utilized as add-ons to the conventional therapy for the management of different ischemic conditions; however, their rigorous clinical assessment is necessary.
缺血是一种致命的疾病，其特征是身体不同器官的灌注受限。活性氧物质和细胞碎片的积累增加是诱导许多氧化、炎症和凋亡信号通路的驱动力。然而，现有的治疗缺血性中风患者的药物数量有限，其疗效的数据也不足，这就需要从天然来源中寻找新的治疗候选药物。本文对已报道的功能性食品生物活性物质（152 种化合物）进行了全面调查，以管理或预防心肌和脑缺血的健康后果。此外，我们还综述了已报道的针对其抗缺血潜力的机制研究。随后，使用已报道的与心肌和脑缺血相关的分子靶标，进行网络药理学和基于网络药理学的研究，以研究它们的复杂相互作用，并突出疾病发病机制中的关键靶标。随后，在综合基于网络药理学的分析（反向对接、Δ计算和分子动力学模拟）中使用文献中最突出的 20 种化合物，以确定这些化合物的其他潜在靶标及其与该疾病相关的不同信号通路的可能相互作用。许多功能性食品生物活性物质，属于不同的化学类别，如类黄酮、皂苷、酚类、生物碱、环烯醚萜和类胡萝卜素，已被证明在针对缺血条件的复杂病理生理学方面具有多因素作用。这些优点使它们成为有价值的治疗剂，可以优于传统药物，因此可以作为传统治疗的附加物，用于管理不同的缺血情况；然而，有必要对它们进行严格的临床评估。
