Symbiosis Centre for Stem Cell Research, Symbiosis International (Deemed University), Pune, 412115, India.
Symbiosis School of Biological Sciences, Symbiosis International (Deemed University), Pune, 412115, India.
Regen Med. 2022 Sep;17(9):677-690. doi: 10.2217/rme-2022-0045. Epub 2022 Jun 15.
Pluripotent stem cells (PSCs) can differentiate into specific cell types and thus hold great promise in regenerative medicine to treat certain diseases. Hence, several studies have been performed harnessing their salutary properties in regenerative medicine. Despite several challenges associated with the clinical applications of PSCs, worldwide efforts are harnessing their potential in the regeneration of damaged tissues. Several clinical trials have been performed using PSCs or their derivatives. However, the delay in publishing the data obtained in the trials has led to a lack of awareness about their outcomes, resulting in apprehension about cellular therapies. Here, the authors review the published papers containing data from recent clinical trials done with PSCs. PSC-derived extracellular vesicles hold great potential in regenerative therapy. Since published papers containing the data obtained in clinical trials on PSC-derived extracellular vesicles are not available yet, the authors have reviewed some of the pre-clinical work done with them.
多能干细胞（PSCs）可以分化为特定的细胞类型，因此在再生医学中具有治疗某些疾病的巨大潜力。因此，已经进行了几项研究，利用其在再生医学中的有益特性。尽管 PSCs 的临床应用存在一些挑战，但全球都在努力挖掘其在受损组织再生中的潜力。已经使用 PSCs 或其衍生物进行了几项临床试验。然而，临床试验数据的延迟发布导致人们对其结果缺乏了解，从而对细胞疗法产生了担忧。在这里，作者回顾了包含最近使用 PSCs 进行的临床试验数据的已发表论文。PSC 衍生的细胞外囊泡在再生治疗中具有巨大的潜力。由于尚未获得包含 PSC 衍生细胞外囊泡临床试验数据的已发表论文，作者回顾了一些使用它们进行的临床前工作。
