Zhai Shuang, Tao Shuman, Wu Xiaoyan, Yang Yajuan, Xiang Jianmin, Xu Yongsheng, Zou Liwei, Xie Yang, Li Tingting, Tao Fangbiao
School of Public Health, Anhui Medical University, Hefei 230032, China.
The Second Hospital of Anhui Medical University, Hefei 230601, China MOE Key Laboratory of Population Health Across Life Cycle/NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei 230032, China.
Wei Sheng Yan Jiu. 2022 May;51(3):353-360. doi: 10.19813/j.cnki.weishengyanjiu.2022.03.002.
To examine the relationship between health-risk behaviors and depressive symptoms among college students, and explore the mediating role of plasma IL-10 level in the relationship between the two.
Freshman students in two universities in Hefei City, Anhui Province and Shangrao City, Jiangxi Province were recruited between April and May 2019, and follow-up investigation was conducted 6 months later. Health risk behaviors were measured based on the Young Risk Behavior Surveillance System(YRBSS) questionnaire, and depressive symptoms was evaluated by using the Depression Anxiety Stress Scale(DASS-21) among college students at baseline and 6 months follow-up survey. Plasma interleukin-10(IL-10) level was measured at baseline. Univariate analysis was used to compare the correlation between health risk behaviors and depressive symptoms among college students. Binary Logistic regression analyzed the relationship between health risk behaviors, IL-10 and depressive symptoms. The mediation model was used to explore the mediating role of IL-10 levels in the association between health risk behaviors and depressive symptoms.
At baseline, boys reported a higher rate of depressive symptoms than that of girls(χ2=6.33, P=0.01); higher rates of depressive symptoms were observed in students who were from a family with a low perceived economic status(χ2=7.31, P=0.03)or in poor health(χ2=6.71, P=0.04). Participants who reported low physical activity(χ2=19.09, P<0.01), smoking(χ2=7.03, P<0.01), and poor sleep quality(χ2=68.78, P<0.01)at baseline were more likely to experience depressive symptoms. Multiple health-risk behaviors at baseline were positively correlated with depressive symptoms among college students. After adjusting gender, self-reported family economy and self-rated health, the regression model showed that plasma IL-10 at baseline was negatively associated with the prevalence of depressive symptoms(OR=0.36, 95% CI 0.18-0.72) and the incidence of depressive symptoms after 6 months(OR=0.20, 95% CI 0.08-0.49). Structural equation model showed that health-risk behaviors was negatively correlated to IL-10 level(β=-0.13, SE=0.04), IL-10 negatively predicted depressive symptoms at follow-up(β=-0.09, SE=0.04), and IL-10 play a mediating role between health risk behavior and depressive symptoms.
Health risk behaviors are positively correlated with depressive symptoms among college students. Plasma IL-10 level at baseline was negatively associated with the incidence of depressive symptoms after 6 months, and IL-10 level at baseline has a partial mediating effect between baseline health risk behavior clustering and depressive symptoms at follow-up.
探讨大学生健康风险行为与抑郁症状之间的关系，并探究血浆白细胞介素-10（IL-10）水平在二者关系中的中介作用。
于2019年4月至5月招募安徽省合肥市和江西省上饶市两所大学的大一学生，并于6个月后进行随访调查。基于青少年风险行为监测系统（YRBSS）问卷测量健康风险行为，在基线和6个月随访调查时使用抑郁焦虑压力量表（DASS-21）评估大学生的抑郁症状。在基线时测量血浆白细胞介素-10（IL-10）水平。采用单因素分析比较大学生健康风险行为与抑郁症状之间的相关性。二元Logistic回归分析健康风险行为、IL-10与抑郁症状之间的关系。采用中介模型探究IL-10水平在健康风险行为与抑郁症状关联中的中介作用。
在基线时，男生报告的抑郁症状发生率高于女生（χ²=6.33，P=0.01）；来自家庭经济状况认知较低（χ²=7.31，P=0.03）或健康状况较差（χ²=6.71，P=0.0４）的学生中抑郁症状发生率较高。在基线时报告身体活动少（χ²=19.09，P<0.01）、吸烟（χ²=7.03，P<0.01）和睡眠质量差（χ²=68.78，P<0.01）的参与者更易出现抑郁症状。基线时多种健康风险行为与大学生抑郁症状呈正相关。在调整性别、自我报告的家庭经济状况和自我评定的健康状况后，回归模型显示基线时血浆IL-１０与抑郁症状的患病率呈负相关（OR=0.36，95%CI 0.18-0.72）以及6个月后抑郁症状的发生率呈负相关（OR=0.20，95%CI 0.08-0.49）。结构方程模型显示健康风险行为与IL-10水平呈负相关（β=-0.13，SE=0.04），IL-10对随访时的抑郁症状有负向预测作用（β=-0.09，SE=0.04），且IL-10在健康风险行为与抑郁症状之间起中介作用。
大学生健康风险行为与抑郁症状呈正相关。基线时血浆IL-10水平与6个月后抑郁症状的发生率呈负相关，且基线时IL-10水平在基线健康风险行为聚集与随访时抑郁症状之间具有部分中介作用。
