Zhou Xuan, Hu Yang, Yang Ziqi, Gong Ziqiang, Zhang Senmao, Liu Xiaoling, Chen Yan, Ye Changxiang, Chen Lizhang, Wang Tingting
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Department of Plastic Surgery of Third Xiangya Hospital, Central South University, Changsha, China.
Front Pediatr. 2022 Jun 3;10:795596. doi: 10.3389/fped.2022.795596. eCollection 2022.
To determine the relationship between childhood overweight/obesity and early puberty in both boys and girls. Specifically, this is the first time to conduct a meta-analysis of the relationship between childhood overweight/obesity and early puberty in boys.
Relevant studies were identified from PubMed, Web of Science, and EMBASE searches. The exposure of interest was overweight/obesity in childhood. Childhood was defined internationally as the age range of 0-18 years. The overall risk estimates were pooled using random effects models. Subgroup and sensitivity analyses were performed to explore possible sources of heterogeneity and to assess the robustness of the results.
A total of 10 studies involving 13,338 girls and 12,796 boys were included. Results showed that childhood overweight/obesity were associated with a significantly higher risk of early puberty in girls [odds ratio (OR): 2.22, 95% CI: 1.65-2.99]. Although without statistical significance, a higher risk of early puberty was also found in boys who were overweight/obese in childhood (OR: 1.29, 95% CI: 0.98-1.70). Heterogeneity in the risk estimates of early puberty was partially explained by study design, sample size, follow-up duration, definitions of early puberty and confounders controlled. Sensitivity analyses validated the robustness of the findings.
Our findings showed that for girls the associate between overweight/obesity and early puberty is definite or strong whereas for males, such an association is possible, prompting that future studies need to further explore the possible relationship between overweight/obesity and early puberty in boys.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021264649, PROSPERO CRD42021264649.
确定儿童超重/肥胖与男孩和女孩青春期提前之间的关系。具体而言，这是首次对儿童超重/肥胖与男孩青春期提前之间的关系进行荟萃分析。
通过检索PubMed、科学网和EMBASE数据库确定相关研究。感兴趣的暴露因素为儿童期超重/肥胖。国际上儿童期定义为0至18岁的年龄范围。使用随机效应模型汇总总体风险估计值。进行亚组分析和敏感性分析，以探索异质性的可能来源并评估结果的稳健性。
共纳入10项研究，涉及13338名女孩和12796名男孩。结果显示，儿童期超重/肥胖与女孩青春期提前风险显著升高相关[比值比（OR）：2.22，95%置信区间（CI）：1.65 - 2.99]。虽然无统计学意义，但在儿童期超重/肥胖的男孩中也发现青春期提前风险较高（OR：1.29，95%CI：0.98 - 1.70）。青春期提前风险估计值的异质性部分可由研究设计、样本量、随访时间、青春期提前的定义以及所控制的混杂因素来解释。敏感性分析验证了研究结果的稳健性。
我们的研究结果表明，超重/肥胖与女孩青春期提前之间的关联是确定的或很强，但对于男性，这种关联是可能的，这提示未来研究需要进一步探索超重/肥胖与男孩青春期提前之间的可能关系。
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202（此处原文可能有误，应为CRD420212）&4649，PROSPERO CRD42021264649。
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