Department of Pediatrics, Nutrition Section, University of Colorado Anschutz Medical Campus, 12801 E 17th Ave. Research Complex 1 South 7th Floor, Aurora, CO, 80045, USA.
Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, 12801 E 17th Ave. Research Complex 1 South 7th Floor, Aurora, CO, 80045, USA.
Curr Diab Rep. 2022 Aug;22(8):371-383. doi: 10.1007/s11892-022-01478-9. Epub 2022 Jun 20.
Despite decades of obesity research and various public health initiatives, obesity remains a major public health concern. Our most drastic but most effective treatment of obesity is bariatric surgery with weight loss and improvements in co-morbidities, including resolution of type 2 diabetes (T2D). However, the mechanisms by which surgery elicits metabolic benefits are still not well understood. One proposed mechanism is through signals generated by the intestine (nutrients, neuronal, and/or endocrine) that communicate nutrient status to the brain. In this review, we discuss the contributions of gut-brain communication to the physiological regulation of body weight and its impact on the success of bariatric surgery. Advancing our understanding of the mechanisms that drive bariatric surgery-induced metabolic benefits will ultimately lead to the identification of novel, less invasive strategies to treat obesity.
尽管几十年来对肥胖症进行了研究，并采取了各种公共卫生措施，但肥胖症仍然是一个主要的公共卫生问题。我们对肥胖症的最激进但最有效的治疗方法是减肥手术和改善合并症，包括解决 2 型糖尿病（T2D）。然而，手术引起代谢益处的机制仍未得到很好的理解。一种提出的机制是通过肠道（营养物、神经元和/或内分泌）产生的信号将营养状况传递给大脑。在这篇综述中，我们讨论了肠道-大脑通讯对体重生理调节的贡献及其对减肥手术成功的影响。深入了解促使减肥手术引起代谢益处的机制最终将导致确定新的、侵入性较小的治疗肥胖症的策略。
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