Laboratório de Endocrinologia Experimental-LEEx, Centro de Ciências da Saúde, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, Bloco F - Sala F1-015 - Ilha do Fundão, Rio de Janeiro, RJ, 21941-912, Brazil.
Programa de Pós-Graduação em Endocrinologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Brain Tumor Pathol. 2022 Oct;39(4):183-199. doi: 10.1007/s10014-022-00441-6. Epub 2022 Jun 20.
Nonfunctioning pituitary neuroendocrine tumors (NF-PitNETs) are tumors that are not associated with clinical evidence of hormonal hypersecretion. According to the World Health Organization (WHO), there are some subtypes of PitNETs that exhibit more aggressive behavior than others. Among the types of potentially aggressive PitNETs, three are nonfunctional: silent sparsely granulated somatotropinomas, silent corticotropinomas, and poorly differentiated PIT-1 lineage tumors. Several biological markers have been investigated in NF-PitNETs. However, there is no single biomarker able to independently predict aggressive behavior in NF-PitNETs. Thus, a more complex and multidisciplinary proposal of a comprehensive definition of aggressive NF-PitNETs is necessary. Here, we suggest a combined and more complete criterion for the NF-PitNETs classification. We propose that aggressiveness is due to a multifactorial combination, and we emphasize the need to include new emerging markers that are involved in the aggressiveness of NF-PitNETs and the need to identify.
无功能性垂体神经内分泌肿瘤（NF-PitNETs）是指与激素过度分泌的临床证据无关的肿瘤。根据世界卫生组织（WHO）的分类，有一些 PitNETs 亚型表现出比其他亚型更具侵袭性的行为。在具有潜在侵袭性的 PitNETs 中，有三种是无功能性的：无功能性稀疏颗粒生长激素细胞瘤、无功能性促肾上腺皮质激素细胞瘤和分化不良的 PIT-1 谱系肿瘤。已经研究了几种生物学标志物在 NF-PitNETs 中的作用。然而，没有单一的生物标志物能够独立预测 NF-PitNETs 的侵袭性行为。因此，需要提出一个更复杂和多学科的综合定义来定义侵袭性 NF-PitNETs。在这里，我们提出了一个更全面的 NF-PitNETs 分类综合标准。我们认为侵袭性是由多种因素共同作用的结果，并且强调需要纳入新出现的与 NF-PitNETs 侵袭性相关的标志物，并需要进行识别。
